… for drug discovery is now complemented by the availability of large (meta)genomic …
discuss such sources of new chemical entities and the implications for drug discovery with a …

… It has been nearly 50 years since the golden age of antibiotic discovery (… novel drug targets
and to deliver new chemical classes of antibiotics to replace those rendered obsolete by drug …

… offering a significant help in drug discovery. In the present review we discuss the importance
of genome mining and synthetic biology approaches to identify new natural products, also …

… approaches to revive antibiotic discovery. We will discuss the stratification of antimicrobial
… approaches to combat drug resistance, an emerging platform combining natural product …

… but rather a compulsion in the drug discovery field so that resistance can be … drugs which
could initiate new ways of thinking about next-generation antimicrobials to resolve the drug …

… the data for the small molecular antibacterial drugs exclusively, we see that natural product
derivatives and natural products together account for 70.6%, synthetic drugs for 28.6%, and …

… for drug discovery within the antibacterial context that are currently being pursued. … agents
under other approaches also discussed in this work) of current antibiotic treatments when …

… to existing drugs for which AMR mechanisms have already emerged 1 , further underscoring
the need for novel approaches in antibiotic discovery. Compounding this issue, antibiotic …

… While the implications of this new approach to antiviral therapy remain to be seen, analogous
paradigmatic shifts are starting to gain momentum in antibacterial drug discovery and must …

… Modern industrial drug discovery, however, has failed to provide new drugs of this … -to-drugs
research paradigm. We posit that the lack of success in new antibiotic drug discovery is due …