[HTML][HTML] Identifying common transcriptome signatures of cancer by interpreting deep learning models

A Jha, M Quesnel-Vallières, D Wang… - Genome Biology, 2022 - Springer
… naive searches for common cancer transcriptome signatures, we sought to train interpretable
deep learning models capable of distinguishing between normal and cancer samples. We …

An overview of mutational and copy number signatures in human cancer

CD Steele, N Pillay, LB Alexandrov - The Journal of Pathology, 2022 - Wiley Online Library
… that mutational signatures of small mutational events have provided in basic science, cancer
treatment, and cancer prevention, and we emphasise the future role that CN signatures may …

[HTML][HTML] A Prognostic Microenvironment-Related Immune Signature via ESTIMATE (PROMISE Model) Predicts Overall Survival of Patients With Glioma

H Qiu, Y Li, S Cheng, J Li, C He, J Li - Frontiers in oncology, 2020 - frontiersin.org
… To our best knowledge, the PROMISE model in the present study has been the first prognostic
signature derived from systematic profiling of immune microenvironment via ESTIMATE …

[HTML][HTML] Prognostic cancer gene expression signatures: current status and challenges

Y Qian, J Daza, T Itzel, J Betge, T Zhan, F Marmé… - Cells, 2021 - mdpi.com
… of using archived specimens, including Formalin-Fixed Paraffin-Embedded (FFPE) samples,
in microarray … Most HCC gene signatures are derived from tumor liver tissues, but some are …

Gene expression signatures: A tool for analysis of breast cancer prognosis and therapy

NR Latha, A Rajan, R Nadhan, S Achyutuni… - Critical Reviews in …, 2020 - Elsevier
signature is a 76 gene signature derived through microarray analysis of 115 breast cancers
(… It is used to predict the prognosis of ER positive as well as ER negative cancers. This 76-…

The clinical relevance of gene expression based prognostic signatures in colorectal cancer

P Ahluwalia, R Kolhe, GK Gahlay - … Acta (BBA)-Reviews on Cancer, 2021 - Elsevier
… with microarray and RNA-sequencing expression data of multiple cancers through TCGA …
Multiple studies have found several gene expression signatures using these databases [41,…

[HTML][HTML] Comprehensive analysis of a nine-gene signature related to tumor microenvironment in lung adenocarcinoma

H Zhong, J Wang, Y Zhu, Y Shen - Frontiers in Cell and …, 2021 - frontiersin.org
… analysis suggested that the prognostic risk model could be an independent prognostic
factor for LUAD patients. A nomogram that incorporated the signature and clinical features was …

[HTML][HTML] MicroRNA: A signature for cancer progression

BM Hussen, HJ Hidayat, A Salihi, DK Sabir… - Biomedicine & …, 2021 - Elsevier
… oncogenic pathways in cancer. Here, we discuss several circulating miRNA signatures,
their expression profiles in different types of cancer and their impacts on cellular processes. …

[HTML][HTML] Classification of breast cancer using microarray gene expression data: A survey

M Abd-Elnaby, M Alfonse, M Roushdy - Journal of Biomedical Informatics, 2021 - Elsevier
… of cancer in order to increase the likelihood of cure. Among the available tools for diagnosing
cancer, microarray technology has been proven to be effective. Microarray technology …

[HTML][HTML] Transcriptomics and Epigenomics in head and neck cancer: available repositories and molecular signatures

MS Serafini, L Lopez-Perez, G Fico, L Licitra… - Cancers of the head & …, 2020 - Springer
… solution when hundreds of samples are profiled for thousands of genes as microarray/RNAseq
and a number of studies on different cancer types proved its robustness [18, 19]. As an …