[HTML][HTML] 'Stem-like' precursors are the fount to sustain persistent CD8+ T cell responses
D Zehn, R Thimme, E Lugli, GP de Almeida… - Nature …, 2022 - nature.com
… T cell populations in latent infections remain functional and … memory-like T cell development
in chronic LCMV infection 67 . … MCMV-specific CD8 + T cells is maintained at a remarkably …
in chronic LCMV infection 67 . … MCMV-specific CD8 + T cells is maintained at a remarkably …
T‐cell heterogeneity, progenitor–progeny relationships, and function during latent and chronic viral infections
… the function of T-cell responses during such chronic infections. … limiting T cell-mediated host
pathology and maintaining the … memory CD8 T cells developed upon an acute infection, still …
pathology and maintaining the … memory CD8 T cells developed upon an acute infection, still …
[HTML][HTML] Stochastic episodes of latent cytomegalovirus transcription drive CD8 T-cell “memory inflation” and avoid immune evasion
M Griessl, A Renzaho, K Freitag, CK Seckert… - Frontiers in …, 2021 - frontiersin.org
… the memory CD8 + T-cell response to natural infections with … by using the Poisson distribution
function as described (54, 55). … -level persistent infection would elegantly explain sustained …
function as described (54, 55). … -level persistent infection would elegantly explain sustained …
[HTML][HTML] Clonally expanded virus-specific CD8 T cells acquire diverse transcriptional phenotypes during acute, chronic, and latent infections
… To profile the virus-specific CD8 T cell response, we leveraged … (C) Fraction of cells belonging
to functional clusters … arising from chronic infection maintain relatively higher expression of …
to functional clusters … arising from chronic infection maintain relatively higher expression of …
T‐cell memory in tissues
KPJM van Gisbergen, KD Zens… - European journal of …, 2021 - Wiley Online Library
… how such continued antigen exposure impacts the function of … infections, as well as those
described in latent and chronic … -2 that maintain essential properties of naïve CD8 + T cells [78, …
described in latent and chronic … -2 that maintain essential properties of naïve CD8 + T cells [78, …
T cell immunity to cytomegalovirus infection
N Zangger, A Oxenius - Current Opinion in Immunology, 2022 - Elsevier
… persists in the infected host in a latent state. In the context of CMV … and the function of
CMV-specific T cell responses, and to … long-term maintained inflationary CD8 T cells which do not …
CMV-specific T cell responses, and to … long-term maintained inflationary CD8 T cells which do not …
The architectural design of CD8+ T cell responses in acute and chronic infection: Parallel structures with divergent fates
… -specific CD8 + T cells and generate functionally diverse T cell … that sustained Ca 2+ /nuclear
factor of activated T cells (NFAT) … For example, during latent viral infections followed by …
factor of activated T cells (NFAT) … For example, during latent viral infections followed by …
[HTML][HTML] Latent CMV infection of Lymphatic endothelial cells is sufficient to drive CD8 T cell memory inflation
…, SM Smart, V Williams, A Tatum, G Xu, T Smith… - PLoS …, 2023 - journals.plos.org
… Large sustained or increasing CD8 T cell responses would … chronic infection are responsible
for the characteristic T cell … Liver sinusoidal ECs share some functional and phenotypic …
for the characteristic T cell … Liver sinusoidal ECs share some functional and phenotypic …
[HTML][HTML] Long-term antiretroviral therapy initiated in acute HIV infection prevents residual dysfunction of HIV-specific CD8+ T cells
…, D Suttichom, P Prueksakaew, T Chalermchai… - …, 2022 - thelancet.com
… Optimizing HIV-specific CD8 + T cell responses has been … infection preserved the functionality
of HIV-specific CD8 + T … of HIV-specific CD8 + T cells exhausted by chronic HIV infection, …
of HIV-specific CD8 + T … of HIV-specific CD8 + T cells exhausted by chronic HIV infection, …
Hallmarks of the aging T‐cell system
… Naïve T cells generated at different stages in life are functionally different, causing age-…
latent EBV and CMV infections may be important for maintaining antigen-specific memory T cells. …
latent EBV and CMV infections may be important for maintaining antigen-specific memory T cells. …