… Building upon FutureTox I, II, and III, this conference focused on the latest science … vitro
profiling and in silico modeling as it relates to predictive developmental and reproductive toxicity (…

… in predictive toxicology as it has shifted from in vivo studies toward in silico studies. Currently…
Therefore, to supplement the results of the search criteria obtained in Tables 1 and 2, we …

… profiling of chemical-bioactivity relationships, and in silico models can support efforts to …
are data gaps that could be addressed with in vitro data and in silico models. Machine-learning …

… 0.001, Table 2), demonstrating that our in vitro- and in silico-based … doses are for predicting
in vivo PODs and informing safety … system and reproductive toxicity were also included in this …

… feature–toxicity relationships to yield predictive models. In this … a model that would be
agnostic of in vitro characteristics, … time spanned 2 orders of magnitude, so we performed a log 2 …

… than the lowest toxicity concentration (in our study, the in vitro BMDL 5 ). This study used
human cell line HK-2 to eliminate extrapolation uncertainty between different species. The HK-…

… two models against the Janesick in vitro results and our own 38-chemical reference set. We
further evaluated the predictive … Most commonly, toxicologists evaluate potential adipogenic …

… to integrate in vivo experimental data with nonclinical data, support … 2 further demonstrated
the goodness of our new AD method. … Predictive toxicology classification models are often …

… from all three were combined or used in “2 out of 3” or a tiered … reproductive toxicity which
was then followed up in the in vitro … of predicting developmental toxicity using in silico models …

… in vitro POD was estimated via human PBTK model. In this study, human cell line HK-2 was
… abundant exposure, metabolic, toxicity and molecular mechanism data, so information 461 …