… of brain tumors given our current understanding of their mechanisms. … -mediated transfer
of the HSVTK gene into primary brain tumors followed by systemic treatment with ganciclovir (…

… mediated cell death associated with GCV, BVDU, and a combinatorial drug treatment, 1:1
HSV/TK + and wild-type NPCs expressing … -TK expressing NPCs were transplanted into a rat …

… for rats with brain tumors treated with the hrR3 HSV vector in the the presence or absence of
ganciclovir. The … immunity following thymidine kinase-mediated killing of experimental brain …

… Background: Glioblastoma multiform (GBM) as a malignant brain tumor has … -mediated
herpes simplex virus thymidine kinase (HSV-TK) gene at frontal focus of tumor besides ganciclovir …

… that tumor rejection was mediated by a potent T-cell anti-tumor … HSV thymidine kinase
gene (HSV-TK) (76, 83) and treatment with ganciclovir, was partially attributable to an anti-tumor …

… -metabolizing enzymes, such as thymidine kinase, ICP34.5, … Conversely, anti-HSV agents,
including ganciclovir and acyclovir, … of heat shock protein 90, which in turn can mediate the …

… herpes simplex virus thymidine kinase (HSV-TK) was performed followed by intravenous
administration of ganciclovir … deep brain tumors, and not evaluating recurrent tumors separately …

… packaging limits, allowing virus-mediated expression of one or … rats harboring brain neoplasms
treated with ganciclovir and a herpes simplex virus vector that retains an intact thymidine …

… the most common primary brain tumors. Gliomas originate from … mediated by inducing an
immune response against the virus. … Thymidine kinase-negative herpes simplex virus mutants …

… of the non-toxic prodrug ganciclovir (GC). GC is then … models have illustrated the ease of
using retrovirus-mediated gene … vector encoding herpes simplex virus thymidine kinase (HSV-…