GM3 Induces Terminal Differentiation of Leukemic Cells

CH Kim, CH Kim - GM3 Signaling, 2020 - Springer
… -induced differentiation of the human leukemic monocytic … lineage cells normally express
a lot of GM3 ganglioside. … during megakaryocytoid differentiation of PMA-induced K562 cells. …

Membrane Ganglioside-Specific Neuraminidase 3 (NEU3) Regulates GM3 Signaling

CH Kim, CH Kim - GM3 Signaling, 2020 - Springer
… ) synthase, blocks the megakaryocytic differentiation in K562 cellsGM3 is an inducing
modulator of megakaryocytoid cell differentiation, as confirmed by human erythroleukemic K562

3′-sialyllactose targets cell surface protein, SIGLEC-3, and induces megakaryocyte differentiation and apoptosis by lipid raft-dependent endocytosis

SH Ha, CH Kwak, JY Park, F Abekura, YC Lee… - Glycoconjugate …, 2020 - Springer
… to the ganglioside GM3 [9]. In the previous study [10, 11], it was shown that GM3 regulates
… To define the type of differentiated cell linage induced by 3SL, K562 cells were treated with …

[图书][B] GM3 Signaling

CH Kim - 2020 - Springer
Ganglioside GM3 has advantages as a potential therapeutic agent. As … -like cell differentiation
can induce monocytic differentiation of human myeloid and monocytoid leukemic cell lines

[HTML][HTML] Inhibition of glycosphingolipid biosynthesis reverts multidrug resistance by differentially modulating ABC transporters in chronic myeloid leukemias

EJ Salustiano, KM da Costa, L Freire-de-Lima… - Journal of Biological …, 2020 - ASBMB
… alter these processes on human leukemias, the expression … a mix of GM1, GM2, and GM3
is indicated on the left of the … than on K562 suggest that this sphingolipid induces collateral …

Regulatory mechanism for the human glioblastoma cell-specific expression of the human GD1c/GT1a/GQ1b synthase (hST8Sia V) gene

SY An, JW Lee, HD Kim, KS Kim, JH Cho, CH Kim… - Glycoconjugate …, 2023 - Springer
induces the increase in the ganglioside GQ1b production in human glioblastoma U87MG cells
was … biosynthesis, such as human GM3 synthase (hST3Gal V) and human GD3 synthase (…

[HTML][HTML] The role of sialyltransferases in gynecological malignant tumors

Y Zhang, R Wang, Y Feng, F Ma - Life Sciences, 2020 - Elsevier
… known as GM3 synthase, in leukemia cell lines HL-60 and k562, … may have a crucial rule in
inducing the expression of ST3Gal5 [24,… of gangliosides and STs in neuroepithelial cells were …