Gardenia jasminoides Enhances CDDP-Induced Apoptosis of Glioblastoma Cells via AKT/mTOR Pathway While Protecting Death of Astrocytes
HI Kim, SH Hong, JM Ku, MJ Kim, SW Ju, SW Chang… - Nutrients, 2020 - mdpi.com
Gliomas are the most observed primary brain tumor, of which glioblastoma multiform (GBM)
shows the highest incidence. Radiotherapy with temozolomide is the standard therapeutic
method, but because of side effects, search for alternative therapies is required. Gardenia
jasminoides (GJ) is flavonoid abundant with beneficial effects on inflammation, metabolic
diseases, and cancers. In this study, we investigated the synergistic combination of GJ and
cisplatin (CDDP) in U87MG and U373MG GBM cells. GJ and CDDP both showed …
shows the highest incidence. Radiotherapy with temozolomide is the standard therapeutic
method, but because of side effects, search for alternative therapies is required. Gardenia
jasminoides (GJ) is flavonoid abundant with beneficial effects on inflammation, metabolic
diseases, and cancers. In this study, we investigated the synergistic combination of GJ and
cisplatin (CDDP) in U87MG and U373MG GBM cells. GJ and CDDP both showed …
Gardenia jasminoides enhances CDDP-induced apoptosis of glioblastoma cells via AKT/mTOR pathway while protecting death of astrocytes.
KHI Kim HyoIn, HSH Hong SeHyang, KJM Ku JinMo… - 2020 - cabidigitallibrary.org
Gliomas are the most observed primary brain tumor, of which glioblastoma multiform (GBM)
shows the highest incidence. Radiotherapy with temozolomide is the standard therapeutic
method, but because of side effects, search for alternative therapies is required. Gardenia
jasminoides (GJ) is flavonoid abundant with beneficial effects on inflammation, metabolic
diseases, and cancers. In this study, we investigated the synergistic combination of GJ and
cisplatin (CDDP) in U87 MG and U373 MG GBM cells. GJ and CDDP both showed …
shows the highest incidence. Radiotherapy with temozolomide is the standard therapeutic
method, but because of side effects, search for alternative therapies is required. Gardenia
jasminoides (GJ) is flavonoid abundant with beneficial effects on inflammation, metabolic
diseases, and cancers. In this study, we investigated the synergistic combination of GJ and
cisplatin (CDDP) in U87 MG and U373 MG GBM cells. GJ and CDDP both showed …
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