… For example, many studies observed mitochondrial damage … are associated with
neurodegeneration in GCLC-KO mice, we … on GSDME functions in the central nervous system; …

… For example, many studies observed mitochondrial damage … examined if neurodegeneration
in the GCLC-KO mouse is … on GSDME functions in the central nervous system; however, our …

… Lou Gehrig’s disease, is a progressive neurodegenerative disease … Conditional GCLC
knockout mice in whole neuronal cells … ROS production and mitochondrial dysfunction were also …

… are targets of ROS, it follows that protection against mitochondrial … mitochondrial antioxidants,
thereby protecting mitochondria from dysfunction and protecting neural cells from damage …

… of GCLC in the cervical spinal cord is due … deficiency of Gclc in mouse CNS leads to
neurodegeneration, specifically progressive motor neuron loss marked by mitochondrial dysfunction […

… to the development of neurodegenerative diseases like Amyotrophic … the occurrence of
mitochondrial dysfunction in the brain of … by an undetectable alteration of GCLc and by a marked …

… of GCLC (p < 0.05), GCLM (p < 0.05) and GSS (p < 0.05). Compared to old-control mice,
the GlyNAC-supplemented old mice had significantly higher protein expression of GCLC (p < …

… GCLM modulates the binding affinity of GCLC by altering the K m … been associated with
neurodegenerative disorders such as … Amongst the major central nervous system (CNS) cells, the …

… neurodegenerative diseases and aging. The general introduction related GSH metabolism to
the extended role of this important antioxidant in the central nervous system (CNS)… in GCLC …

… In the mitochondria, electrons escape from complex I and complex II, on the electron
transport chain (ETC), causing oxygen reduction to form O 2 ·- . Consequently, O 2 ·- is rapidly …