Resistance to gemcitabine in pancreatic ductal adenocarcinoma: A physiopathologic and pharmacologic review
T Koltai, SJ Reshkin, TMA Carvalho, D Di Molfetta… - Cancers, 2022 - mdpi.com
… Resistance to gemcitabine and other chemotherapeutic drugs is an essential factor in this
failure. This review analyzes the molecular causes of gemcitabine resistance … in pancreatic …
failure. This review analyzes the molecular causes of gemcitabine resistance … in pancreatic …
Systematic exploration of the underlying mechanism of gemcitabine resistance in pancreatic adenocarcinoma
K Liu, Y Geng, L Wang, H Xu, M Zou, Y Li… - Molecular …, 2022 - Wiley Online Library
… Resistance to gemcitabine is the main challenge of chemotherapy for pancreatic ductal
adenocarcinoma … Hence, the development of a response signature to gemcitabine is essential for …
adenocarcinoma … Hence, the development of a response signature to gemcitabine is essential for …
CD73 induces gemcitabine resistance in pancreatic ductal adenocarcinoma: A promising target with non-canonical mechanisms
X Yu, W Liu, Z Wang, H Wang, J Liu, C Huang, T Zhao… - Cancer Letters, 2021 - Elsevier
… of CD73 in pancreatic ductal adenocarcinoma (PDAC). Our findings support that the elevated
expression of CD73 in PDAC cells promotes gemcitabine (GEM) resistance by activating …
expression of CD73 in PDAC cells promotes gemcitabine (GEM) resistance by activating …
… LIG1 transcription by binding to FOXA1/TET1 to enhance the DNA damage response and promote gemcitabine resistance in pancreatic ductal adenocarcinoma
L Xu, X Ma, X Zhang, C Zhang, Y Zhang, S Gong… - Molecular Cancer, 2023 - Springer
… assays were used to analyze the proliferation, apoptosis and gemcitabine (GEM) resistance
of pancreatic ductal adenocarcinoma (PDAC) cells. Xenograft model and IHC experiments …
of pancreatic ductal adenocarcinoma (PDAC) cells. Xenograft model and IHC experiments …
Gemcitabine resistance in pancreatic ductal carcinoma cell lines stems from reprogramming of energy metabolism
R Fujiwara-Tani, T Sasaki, T Takagi, S Mori… - International Journal of …, 2022 - mdpi.com
… pancreatic ductal carcinoma cell lines were treated with continuous GEM to confirm the
hypothesis about GEM resistance in … ) did not induce GEM resistance, whereas the other two cell …
hypothesis about GEM resistance in … ) did not induce GEM resistance, whereas the other two cell …
Genome-wide CRISPR screen identifies MTA3 as an inducer of gemcitabine resistance in pancreatic ductal adenocarcinoma
L Wu, Y Ge, Y Yuan, H Li, H Sun, C Xu, Y Wang… - Cancer Letters, 2022 - Elsevier
… Gemcitabine (GEM) resistance is one of the major causes of treatment failure in pancreatic
ductal adenocarcinoma … that MTA3 mediates the GEM resistance of PDAC and thus might be …
ductal adenocarcinoma … that MTA3 mediates the GEM resistance of PDAC and thus might be …
… promotes cancer progression and gemcitabine resistance through modulation of EMT and ATP-binding cassette transporters in pancreatic ductal adenocarcinoma
Y Okada, N Takahashi, T Takayama, A Goel - Carcinogenesis, 2021 - academic.oup.com
… Considering that overexpression of LAMC2 is associated with gemcitabine resistance in our
… of gemcitabine resistance in PC cells. Therefore, we examined the gemcitabine sensitivity of …
… of gemcitabine resistance in PC cells. Therefore, we examined the gemcitabine sensitivity of …
Circular RNA circ-MTHFD1L induces HR repair to promote gemcitabine resistance via the miR-615-3p/RPN6 axis in pancreatic ductal adenocarcinoma
ZW Chen, JF Hu, ZW Wang, CY Liao, FP Kang… - Journal of Experimental …, 2022 - Springer
… in human pancreatic cancer cell lines and gemcitabine resistant pancreatic cancer cell lines
… GEO, and discovered a new gemcitabine resistant-related molecule in pancreatic cancer: …
… GEO, and discovered a new gemcitabine resistant-related molecule in pancreatic cancer: …
HIF‐1α‐regulated stanniocalcin‐1 mediates gemcitabine resistance in pancreatic ductal adenocarcinoma via PI3K/AKT signaling pathway
F Zhao, G Yang, J Qiu, Y Liu, J Tao… - Molecular …, 2022 - Wiley Online Library
… gemcitabine resistance, we divided postoperative patients into gemcitabine treatment
groups and non-gemcitabine … survival in gemcitabine treatment groups, but not in non-gemcitabine …
groups and non-gemcitabine … survival in gemcitabine treatment groups, but not in non-gemcitabine …
[HTML][HTML] Therapeutic resistance in pancreatic ductal adenocarcinoma: Current challenges and future opportunities
A Jain, V Bhardwaj - World journal of gastroenterology, 2021 - ncbi.nlm.nih.gov
… gemcitabine resistance, as HK2 dimerization is enhanced in cells that do not respond to
gemcitabine… of HK2 enhanced the sensitivity of PDAC to gemcitabine. Similarly, in another study, …
gemcitabine… of HK2 enhanced the sensitivity of PDAC to gemcitabine. Similarly, in another study, …
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