Improving molecular therapy in the kidney

JD Rubin, MA Barry - Molecular diagnosis & therapy, 2020 - Springer
… in gene delivery to the kidney and the field of gene therapy … of kidney genetics to work toward
developing gene therapy … to a rat kidney destined for kidney transplantation over the course …

[HTML][HTML] Gene therapy clinical trials, where do we go? An overview

F Arabi, V Mansouri, N Ahmadbeigi - Biomedicine & Pharmacotherapy, 2022 - Elsevier
gene therapy, we reviewed current gene therapy products as well as gene therapies that may
be approved in the near futuregenetic diseases, may show higher efficacy and feasibility of …

The horizon of gene therapy in modern medicine: advances and challenges

B Arjmand, B Larijani, M Sheikh Hosseini… - Cell Biology and …, 2020 - Springer
… As mentioned before, therapeutic efficacy following gene therapy has now been reported
for several inherited diseases including SCID-X1, ADA-SCID, CGD, LCA, …

[HTML][HTML] Recent advances and clinical outcomes of kidney transplantation

C Thongprayoon, P Hansrivijit, N Leeaphorn… - Journal of Clinical …, 2020 - mdpi.com
… Although several studies have suggested the safe use of sodium glucose transport 2 (SGLT2)
inhibitors in kidney transplant recipients [128], future studies assessing their efficacy and …

[HTML][HTML] Complement-targeted therapies in kidney transplantation—Insights from preclinical studies

IJ Anwar, I DeLaura, J Ladowski, Q Gao… - Frontiers in …, 2022 - frontiersin.org
… ) to assess safety and efficacy of eculizumab as ABMR prevention following HLA-incompatible
kidney transplantation was terminated due to lack of … Future directions and conclusion …

[HTML][HTML] The future of gene therapy for transfusion-dependent beta-thalassemia: The power of the lentiviral vector for genetically modified hematopoietic stem cells

P Rattananon, U Anurathapan, K Bhukhai… - Frontiers in …, 2021 - frontiersin.org
new era of medicine. Many researchers have attempted to develop and modify novel strategies
to improve future directions of HSC gene therapy… outcome with effectiveness are urgently …

[HTML][HTML] IL-6 directed therapy in transplantation

CL Miller, JC Madsen - Current transplantation reports, 2021 - Springer
… shown efficacy in single-arm, pilot trials aimed at reducing HLA antibody in highly sensitized
patients awaiting kidney transplantation … In this study, 30 kidney transplant recipients with …

[HTML][HTML] Gene therapy strategies for idiopathic pulmonary fibrosis: recent advances, current challenges, and future directions

MJR Ruigrok, HW Frijlink, BN Melgert, P Olinga… - Molecular Therapy …, 2021 - cell.com
… to gene therapy. We then present an evaluation of published animal studies to establish
whether gene therapy could be a feasible therapeutic … to transform gene therapy concepts into …

Donor-derived cell-free DNA in solid-organ transplant diagnostics: indications, limitations, and future directions

A Kataria, D Kumar, G Gupta - Transplantation, 2021 - journals.lww.com
… focuses on kidney transplants, there are several recent as well as ongoing research studies
on … Finally, cost-effectiveness studies will be needed to guide the ideal incorporation of dd-…

[HTML][HTML] Current and future directions of stem cell therapy for bladder dysfunction

JH Shin, CM Ryu, HY Yu, DM Shin… - Stem Cell Reviews and …, 2020 - Springer
… perivascular-like structure up to 30 days after transplantation [74]. These reports from the
Choo group provide the first evidence for improved therapeutic efficacy, long-term safety, and in …