… -wide association study (GWAS) derived signals across ancestral groups highlighted these
differences, especially in Africans, despite the shared genetic architecture for lipid traits 22 . …

… are key contributors to the development of clinical HF, and these traits share genetic architecture,
we … For the Mendelian Randomization analysis of lipoprotein(a), a secondary genetic …

… The genetic architecture of FCHL remains incompletely … identify it, and the presumed complex
genetic inheritance [6,16,17]. … common SNVs related to plasma lipoprotein traits, and that it …

… The present results demonstrated extensive overlapping polygenic architecture … genetic
correlation. We identified 345 unique genetic loci underlying the shared genetic architecture, …

… The genetic architecture of FH has long been held to be monogenic. Indeed, in numerous
… in the LDLR gene, which can be explained by the increased clearance of certain lipoprotein …

… part, genetically determined and that genetic interrogation of this metabolite would reveal
novel underlying biology of cardiometabolic disease. We examined the genetic contribution to …

… Determine how the genetic architecture of LPA accounts for differences in Lp(a) levels in
different ancestry groups. Studies using properly processed samples and reliable methods for …

… This review provides a comprehensive overview on the complex genetic architecture of
the Lp(a) concentrations in plasma, a field that has made tremendous progress with the …

… polygenic disorders, it became apparent that genetic linkage analysis would not be the most
appropriate technique to pursue their genetic architecture. Linkage analysis has low power …

… Genetic variants have been identified as significant … traits and diseases, such as
dyslipidemia and lipid levels (low-density lipoprotein cholesterol (LDL), high-density lipoprotein …