Integrating Biology With Rat Genomic Tools
MR Dwinell, AM Geurts - The Laboratory Rat, 2020 - Elsevier
… This improved genetic map was shown to impact the … Consomic and congenic strains
were developed to have a strain of rats or panel of rat strains to validate findings from genetic …
were developed to have a strain of rats or panel of rat strains to validate findings from genetic …
Taxonomy and stocks and strains
HJ Hedrich - The Laboratory Rat, 2020 - Elsevier
… of endonucleases, genetic modifications in rats have become … -density genetic maps with
the aim of mapping disease genes. … By comparing the characteristics of consomic strains with …
the aim of mapping disease genes. … By comparing the characteristics of consomic strains with …
[HTML][HTML] … imaging and machine learning framework for stratifying high vs. low notch-Dll4 expressing host microenvironment in triple-negative breast cancer
… Consomic Xenograft Model (CXM) as a strategy for mapping … green (ICG) through a tail
vein in tumor-bearing rats, and … vascular-specific Dll4 allele on rat chromosome 3 (RNO3) as a …
vein in tumor-bearing rats, and … vascular-specific Dll4 allele on rat chromosome 3 (RNO3) as a …
Descending Control of Nociception Poorly Predicts the Development of Persistent Postsurgical Pain-like Behavior in Consomic Dahl S Rat Strains
LF Ferrari, A Wilkinson, C Cahoon, A Ramirez… - …, 2023 - pubs.asahq.org
… In this study, we utilized a partial panel of consomic rats … (Scl6a4) and TRPV1 genes on
chromosome 10 were not available … In conclusion, we have identified several novel rat models of …
chromosome 10 were not available … In conclusion, we have identified several novel rat models of …
[HTML][HTML] Heritable modifiers of the tumor microenvironment influence nanoparticle uptake, distribution and response to photothermal therapy
… Methods: We generated two consomic rat strains with differing DLL4 expression on 3 rd …
rats with 3rd chromosome substituted from Brown Norway rat. We further constructed three novel …
rats with 3rd chromosome substituted from Brown Norway rat. We further constructed three novel …
Genetic basis of cardiometabolic disease in the Lyon Hypertensive rat
KC Clark - 2022 - search.proquest.com
… years of my life, the rats made the ultimate sacrifice for me to … Next, we utilized a consomic
rat strain to show that replacement … Genetic mapping studies implicate chromosome 17 (chr17) …
rat strain to show that replacement … Genetic mapping studies implicate chromosome 17 (chr17) …
Rare disease research resources at the rat genome database
ML Kaldunski, JR Smith, KC Brodie, JL De Pons… - Genetics, 2023 - academic.oup.com
… a modified chromosome (consomic) or modified chromosomal … Beyond rats being used
as models of common and rare … Genetic maps have been used successfully to find genes …
as models of common and rare … Genetic maps have been used successfully to find genes …
Laboratory animal genetics and genetic quality control
MFW Festing, C Lutz - Handbook of laboratory animal science, 2021 - api.taylorfrancis.com
… various types of cancer, such as mammary tumors in C3H and … been used for genetic mapping
and genetic quality control. … of consomic rat strains with chromosomes from BN strain rats …
and genetic quality control. … of consomic rat strains with chromosomes from BN strain rats …
[HTML][HTML] Advances in preclinical research models of radiation-induced cardiac toxicity
RA Schlaak, G SenthilKumar, M Boerma, C Bergom - Cancers, 2020 - mdpi.com
… The inbred SS rat strain is more sensitive to RIHD than the inbred BN rat strain [49], as well
as consomic SS.BN3 rats (genetically identical to SS rats except for chromosome 3, which is …
as consomic SS.BN3 rats (genetically identical to SS rats except for chromosome 3, which is …
Identifying Genetic Modifiers of Radiation-Induced Cardiac Dysfunction Using Pre-Clinical Models
RA Schlaak - 2020 - search.proquest.com
… This led to the use of consomic rats, with the same genetic … Congenic rats, with portions of
BN rat chromosome 3 in the SS … as well as identifying novel targets for therapeutic intervention. …
BN rat chromosome 3 in the SS … as well as identifying novel targets for therapeutic intervention. …