Importance of the pig as a human biomedical model

JK Lunney, A Van Goor, KE Walker… - Science translational …, 2021 - science.org
… The ability to generate customized animals, using surgical or … to animals produced through
all types of genetic engineering: … and future pig biomedical models, eg, using humanized pig

Transgenic pigs for islet xenotransplantation

PJ Cowan - Pancreas and Beta Cell Replacement, 2022 - Elsevier
… long-lasting xenograft survival in humanized mice without … Human insulin and C-peptide
were detected in these pigs, … genetic modifications for “naked” porcine islets delivered into

Characterisation of transgenic pigs expressing a human T cell‐depleting anti‐CD2 monoclonal antibody

EJ Salvaris, N Fisicaro, S McIlfatrick… - …, 2024 - Wiley Online Library
… the prospect of using genetically modified (GM) pig organs to … using 1x TaqMan Gene
expression master mix and custom … test NICCs from the MHCIP-diliximab pigs in humanized mice…

Double transgenic neonatal porcine islets as an alternative source for beta cell replacement therapy

NI Mourad, A Perota, D Xhema, R Duchi… - Proceedings of the …, 2024 - pnas.org
… the generation of genetically modified pigs from which “… to treat insulin-dependent diabetes
in an immunodeficient pig-… Our expression cassette inserted in a customized targeting …

Multiple gene modifications of pigs for overcoming obstacles of xenotransplantation

H Wu, M Lian, L Lai - National Science Open, 2023 - nso-journal.org
… in the pig insulin gene and produced a humanized pig that exclusively secretes human
insulin, … Conventionally, genetically modified pigs were produced using genetically modified …

[HTML][HTML] Genetically engineered porcine organs for human xenotransplantation

M Shahab, NU Din, N Shahab - Cureus, 2022 - ncbi.nlm.nih.gov
pigs that produced human insulin [18]. Even though the genetically modified swine produced
human insulin… employed to create insulin-deficient pigs, whereas SCNT was used to create …

[HTML][HTML] Genetic engineering drives the breakthrough of pig models in liver disease research☆

C Xu, X Fang, X Xu, X Wei - Liver Research, 2024 - Elsevier
… as donors for large-scale production of humanized livers is … piglets, with higher visceral fat
mass and greater insulin … models, providing more opportunities to customize target forms while …

[HTML][HTML] Hypoimmune induced pluripotent stem cells survive long term in fully immunocompetent, allogeneic rhesus macaques

X Hu, K White, AG Olroyd, R DeJesus… - Nature …, 2024 - nature.com
Genetic engineering of allogeneic cell therapeutics that fully … in immunocompetent, allogeneic
diabetic humanized mice for 4 … into an unmodified subcutaneous site in large animals and …

[HTML][HTML] Developing Humanized Animal Models with Transplantable Human iPSC-Derived Cells

M Ma, JY Ge, YZ Nie, YM Li, YW Zheng - Frontiers in Bioscience …, 2024 - imrpress.com
… to be overcome to generate fully humanized animals. Recent … with humans and ability to be
easily genetically edited, small … Moreover, “Designed red cells” with custom phenotypes (Rh …

[HTML][HTML] Pigs with an INS point mutation derived from zygotes electroporated with CRISPR/Cas9 and ssODN

F Tanihara, M Hirata, Z Namula, LTK Do… - Frontiers in Cell and …, 2023 - frontiersin.org
genetically modified pigs that secreted human insulin; these … , we generated five genetically
modified pigs carrying various … which suggests the secretion of functional humanized insulin. …