[HTML][HTML] Genome-wide modeling of polygenic risk score in colorectal cancer risk
M Thomas, LC Sakoda, M Hoffmeister… - … of human genetics, 2020 - cell.com
… In this paper, we derived and compared different approaches to generating predictive
polygenic risk scores (PRS) from genome-wide association studies (GWASs) including 55,105 …
polygenic risk scores (PRS) from genome-wide association studies (GWASs) including 55,105 …
Genome-wide analysis provides genetic evidence that ACE2 influences COVID-19 risk and yields risk scores associated with severe disease
…, Regeneron Genetics Center RGC Management and … - … genetics, 2022 - nature.com
… In this study, we performed a genome-wide association study (GWAS) meta-analysis to …
Our analysis identified a new association between a rare variant near the ACE2 gene that …
Our analysis identified a new association between a rare variant near the ACE2 gene that …
Genetics of diabetes mellitus and diabetes complications
… through genome-wide association studies, and emphasize the gaps in research for taking
… major environmental and genetic components. When early studies identified differences in …
… major environmental and genetic components. When early studies identified differences in …
Genetic proxy of lipid-lowering drugs and calcific aortic valve stenosis: a Mendelian randomization study
Y Hou, J Zhao, W Xu, L Chen, J Yang, Z Wang, K Si - Heliyon, 2024 - cell.com
… genes, and genetic variants within or near drug target genes that … concentrations from
Genome-Wide Association Studies (… Large-scale cis- and trans-eQTL analyses identify thousands …
Genome-Wide Association Studies (… Large-scale cis- and trans-eQTL analyses identify thousands …
FTO–a common genetic basis for obesity and cancer
N Lan, Y Lu, Y Zhang, S Pu, H Xi, X Nie, J Liu… - … in genetics, 2020 - frontiersin.org
… fat mass and obesity-associated (FTO) genes are linked, taking into account a Genome-wide
Association … (SNPs) of the FTO gene, indicating an association between obesity and cancer …
Association … (SNPs) of the FTO gene, indicating an association between obesity and cancer …
Integrated lipidomic and transcriptomic analyses identify altered nerve triglycerides in mouse models of prediabetes and type 2 diabetes
… saturated fatty acids. In parallel, transcriptomic analysis confirmed the dysregulation of lipid
… Integration of lipidomic and transcriptomic analyses identified an increase in diacylglycerol …
… Integration of lipidomic and transcriptomic analyses identified an increase in diacylglycerol …
GWAS of allometric body-shape indices in UK Biobank identifies loci suggesting associations with morphogenesis, organogenesis, adrenal cell renewal and cancer
… We performed the first genome-wide association study of A Body Shape Index (ABSI), Hip
Index (HI) and the new Waist-to-Hip Index and compared these with traditional indices, using …
Index (HI) and the new Waist-to-Hip Index and compared these with traditional indices, using …
[HTML][HTML] Meta-analysis uncovers genome-wide significant variants for rapid kidney function decline
… In contrast to cross-sectionally assessed eGFRcrea, the genetic basis for rapid eGFRcrea …
-analyzed 42 genome-wide association studies from the Chronic Kidney Diseases Genetics …
-analyzed 42 genome-wide association studies from the Chronic Kidney Diseases Genetics …
Discovery of 318 new risk loci for type 2 diabetes and related vascular outcomes among 1.4 million participants in a multi-ancestry meta-analysis
… We next performed phenome-wide association analysis (PheWAS) for each of the three …
interaction analyses identified several loci at which the association between a genetic variant …
interaction analyses identified several loci at which the association between a genetic variant …
Twelve years of GWAS discoveries for osteoporosis and related traits: advances, challenges and applications
… and genetic factors. In this review, we first summarize the discovery from genome-wide
association studies (… Another multistage GWAS meta-analysis identified a novel heel SOS locus (…
association studies (… Another multistage GWAS meta-analysis identified a novel heel SOS locus (…