[HTML][HTML] Comparative transcriptome analysis identifies CARM1 and DNMT3A as genes associated with osteoporosis

L Panach, C Pertusa, B Martínez-Rojas, Á Acebrón… - Scientific Reports, 2020 - nature.com
… were (i) history of bone disease other than primary osteoporosis, (ii) hyperparathyroidism, …
1A) shows that overall gene expression is different across the two groups, although OB data …

[HTML][HTML] Epigenetic DNA methylation signatures associated with the severity of paget's disease of bone

I Diboun, S Wani, SH Ralston… - Frontiers in Cell and …, 2022 - frontiersin.org
… dysregulated bone turnover resulting in increased bone loss … A recent study has identified
many differentially methylated … and could reveal additional differentially methylation loci …

A road map for understanding molecular and genetic determinants of osteoporosis

TL Yang, H Shen, A Liu, SS Dong, L Zhang… - Nature Reviews …, 2020 - nature.com
… 53,54 have reported that genetic profiling of BMD-associated … of human bone detected 241
differentially methylated CpG … human osteoblasts and osteocytes revealed that the genes that …

Lipid Metabolism, Methylation Aberrant, and Osteoporosis: A Multi-omics Study Based on Mendelian Randomization

ZL Zhang, YC Duan, JZ Huo - Calcified Tissue International, 2024 - Springer
… of lipid profile-associated methylation sites and bone mineral … also showed that differential
methylation profiles in whole … of osteoporosis, suggesting that methylation regulation also …

[HTML][HTML] The role of epigenomics in osteoporosis and osteoporotic vertebral fracture

KT Kim, YS Lee, I Han - International journal of molecular sciences, 2020 - mdpi.com
shows that elevation of Kdm5a is confirmed in osteoporosis MSC. Kdm5a inhibits bone
formation in an osteoporosis … a Kdm5a inhibitor partially alleviates bone loss in osteoporosis [62]. …

[HTML][HTML] Comprehensive analysis of the m6A-related molecular patterns and diagnostic biomarkers in osteoporosis

Q Bai, M Shi, X Sun, Q Lou, H Peng, Z Qu… - Frontiers in …, 2022 - frontiersin.org
Osteoporosis (OP), one of the most common bone system … reduction method to reveal
population stratification at different … the mRNA expression profile of the above DE-m6A regulators. …

[HTML][HTML] DNA methylation analysis identifies key transcription factors involved in mesenchymal stem cell osteogenic differentiation

R Gómez, MJ Barter, A Alonso-Pérez, AJ Skelton… - Biological …, 2023 - SciELO Chile
… our osteoblastogenesis differentially methylated regions with … , bone marrow adiposity has
been associated with bone loss in … in human pathological bone samples revealed a potential …

[HTML][HTML] The roles of epigenetics regulation in bone metabolism and osteoporosis

F Xu, W Li, X Yang, L Na, L Chen, G Liu - Frontiers in cell and …, 2021 - frontiersin.org
… -wide signature of hMSCs from fracture patients shows differentially methylated regions
in … In 2017, Fernandez-Rebollo et al., analyzed genome wide DNA methylation profiles of …

Epigenetic analysis of Paget's disease of bone identifies differentially methylated loci that predict disease status

I Diboun, S Wani, SH Ralston, OME Albagha - Elife, 2021 - elifesciences.org
… in DNA methylation profiles in … gene body often stimulates gene expression (Figure 1).
Evaluation of the 25,773 CpG islands on the array revealed 978 differentially methylated regions (…

Recent advances in the epigenetics of bone metabolism

Y Xu, J Ma, G Xu, D Ma - Journal of bone and mineral metabolism, 2021 - Springer
Osteoporosis is a common form of metabolic bone disease … in BMD, and the differentially
methylated CpG sites most … Microarray-based profiling of circRNAs has also revealed that …