Epigenetic regulation of skeletal tissue integrity and osteoporosis development

YS Chen, WS Lian, CW Kuo, HJ Ke, SY Wang… - International Journal of …, 2020 - mdpi.com
methylation, microRNA, and histone modification and highlights their interactions during
skeletal development and bone lossrevealed that over 500 gene loci are associated with bone

Associations between epigenome-wide DNA methylation and height-related traits among Sub-Saharan Africans: the RODAM study

G Swart, K Meeks, F Chilunga, A Venema… - … Origins of Health and …, 2023 - cambridge.org
… hypothesized as contributing to osteoporosis as well as other … Epigenetic profiles derived
from bone-related tissues would … differentially methylated region identified HOXA cluster gene

Epigenetics of Osteoporosis

O Bischof, R Ebert, H Taipaleenmäki, E Hesse… - …, 2021 - thieme-connect.com
… Impaired bone formation, accelerated bone loss, and … blood leukocytes from osteoporosis
patients that reveal novel disease … CpG islands differentially methylated in osteoporosis versus …

Identification of ferroptosis-associated biomarkers for the potential diagnosis and treatment of postmenopausal osteoporosis

Y Hu, J Han, S Ding, S Liu, H Wang - Frontiers in Endocrinology, 2022 - frontiersin.org
… To prevent bone loss, a proactive approach is recommended … We then curated the expression
profiles of the DEFAGs for … OP can be revealed through the study of OP candidate gene

[HTML][HTML] Reduced CpG island methylation of the TBC1D8 gene may predict risk for osteoporosis in Chinese postmenopausal women

QQ Ma, L Lin, Q Yao, J Yang, Y Hu, JB Yu - Oncotarget, 2020 - ncbi.nlm.nih.gov
… Study that contained 7633 Caucasian women and 3657 men revealed that 2q 11.2 of …
differences in genome wide methylation in bone cells from the femoral head region of patients with …

Role of epigenetic regulatory mechanisms in age‐related bone homeostasis imbalance

Y Zhong, X Zhou, Z Pan, J Zhang, J Pan - The FASEB Journal, 2024 - Wiley Online Library
… Recent studies on bone aging have revealed that cytokine … aging- associated differentially
methylated regions. Generally… be inhibited in osteoporosis or agerelated bone loss, and is …

Screening and Analysis of Core Genes for Osteoporosis Based on Bioinformatics Analysis and Machine Learning Algorithms

Y Lu, W Wang, B Yang, G Cao, Y Du, JY Liu - Indian Journal of …, 2024 - Springer
… mRNA expression profiles of osteoporosis patients were … Osteoporosis (OP) is a prevalent
bone disease that reduces … Further investigations reveal that reducing miR-133a levels inhibits …

Prioritization of genes relevant to bone fragility through the unbiased integration of aging mouse bone transcriptomics and human GWAS analyses

S Kaya, CA Schurman, NS Dole… - Journal of Bone and …, 2020 - academic.oup.com
… imbalanced bone remodeling and progressive bone loss, … profile in aging bone, pathway
analysis revealed few … DEGs in each aging gene set were most enriched for the same KEGG …

Precision Medicine: Pharmacogenetics and Pharmacogenomics of Osteoporosis

Y El Miedany - New Horizons in Osteoporosis Management, 2022 - Springer
… in bone, there is still an unmet gap in our knowledge about pharmacogenomics and
pharmacogenetics of osteoporosis… in osteoporosis treatment by comparing the expression profiles

Transcriptome-wide m6A methylome during osteogenic differentiation of human adipose-derived stem cells

W Sun, Y Song, K Xia, L Yu, X Huang, Z Zhao… - Stem Cell Research & …, 2021 - Springer
… of bone biology, m 6 A modification plays critical roles in bone development as well as bone
diseases such as osteoporosis… these differentially methylated and regulated genes revealed