Dimensional and transdiagnostic phenotypes in psychiatric genome-wide association studies

MA Waszczuk, KG Jonas, M Bornovalova, G Breen… - Molecular …, 2023 - nature.com
Genome-wide association studies (GWAS) provide biological insights into disease onset
and progression and have potential to produce clinically useful biomarkers. A growing body of …

Genome wide association study identifies four loci for early onset schizophrenia

S Guo, J Liu, W Li, Y Yang, L Lv, X Xiao, M Li… - Translational …, 2021 - nature.com
… architecture of SCZ, multiple genome-wide association studies (GWASs) have … of psychiatric
disorders were collected and evaluated. The age at first manifestation of positive symptoms

Integrated analysis of direct and proxy genome wide association studies highlights polygenicity of Alzheimer's disease outside of the APOE region

J de la Fuente, AD Grotzinger, RE Marioni… - PLoS …, 2022 - journals.plos.org
… Recent meta-analyses combining direct genome-wide association studies (GWAS) with
those of family history (GWAX) have indicated very low SNP heritability of Alzheimer’s disease (…

Toward a Full Understanding of Causal and Modifiable Risk Factors for Alzheimer's Disease by Integrative Phenome-wide Association Studies

DF Zhang, M Li - Biological Psychiatry, 2023 - biologicalpsychiatryjournal.com
… The AD-PRS was generated based on genetic variants from the remarkable AD genome-wide
association study provided by the International Genomics of Alzheimer’s Project. The …

Integrative analysis of genome-wide association studies identifies novel loci associated with neuropsychiatric disorders

X Yao, JT Glessner, J Li, X Qi, X Hou, C Zhu… - Translational …, 2021 - nature.com
… ranging from 40 to 88% 13,14,15,16,17,18,19,20 , and a number of genome-wide
genome-wide association studies (GWASs), especially through the collective effort of the Psychiatric

A phenome-wide association and Mendelian randomization study for Alzheimer's disease: A prospective cohort study of 502,493 participants from the UK Biobank

SD Chen, W Zhang, YZ Li, L Yang, YY Huang… - Biological …, 2023 - Elsevier
… AD is a hereditary disease. The heritability is estimated to be between 60% and 80% (4).
Recent genome-wide association studies (GWASs) conducted by Schwartzentruber et al. (5) …

A genome-wide association study of tinnitus reveals shared genetic links to neuropsychiatric disorders

IS Bhatt, N Wilson, R Dias, A Torkamani - Scientific reports, 2022 - nature.com
… accompanied by psychiatric comorbidities. Recent genome-wide association studies (GWAS) …
A shared genetic component between tinnitus and psychiatric conditions remains elusive. …

Multi-ancestry genome-wide association study of cannabis use disorder yields insight into disease biology and public health implications

DF Levey, M Galimberti, JD Deak, FR Wendt… - Nature Genetics, 2023 - nature.com
… Here we performed a genome-wide association study of … We discovered genome-wide
significant loci unique to each … and psychiatric public health consequences that require further …

Adolescent verbal memory as a psychosis endophenotype: a genome-wide association study in an ancestrally diverse sample

B Wang, O Giannakopoulou, I Austin-Zimmerman… - Genes, 2022 - mdpi.com
… deficits in psychosis. However, few studies have investigated the genetic basis of verbal
memory in a neurodevelopmental context, and most genome-wide association studies (GWASs) …

A genome-wide association study for melatonin secretion

PH Liu, GT Chuang, CN Hsiung, WS Yang, HC Ku… - Scientific Reports, 2022 - nature.com
… Individuals with a record of neurological disorders or psychiatric illnesses were excluded …
Patients with neurodegenerative disorder such as Alzheimer's disease exhibit reduced serum …