Genome-wide association study of pediatric obsessive-compulsive traits: shared genetic risk between traits and disorder
CL Burton, M Lemire, B Xiao, EC Corfield… - Translational …, 2021 - nature.com
Using a novel trait-based measure, we examined genetic variants associated with obsessive-
compulsive (OC) traits and tested whether OC traits and obsessive-compulsive disorder
(OCD) shared genetic risk. We conducted a genome-wide association analysis (GWAS) of
OC traits using the Toronto Obsessive-Compulsive Scale (TOCS) in 5018 unrelated
Caucasian children and adolescents from the community (Spit for Science sample). We
tested the hypothesis that genetic variants associated with OC traits from the community …
compulsive (OC) traits and tested whether OC traits and obsessive-compulsive disorder
(OCD) shared genetic risk. We conducted a genome-wide association analysis (GWAS) of
OC traits using the Toronto Obsessive-Compulsive Scale (TOCS) in 5018 unrelated
Caucasian children and adolescents from the community (Spit for Science sample). We
tested the hypothesis that genetic variants associated with OC traits from the community …
Genome-Wide Association Study of Obsessive-Compulsive Symptoms including 33,943 individuals from the general population
Abstract While 1–2% of individuals meet the criteria for a clinical diagnosis of obsessive-
compulsive disorder (OCD), many more (~ 13–38%) experience subclinical obsessive-
compulsive symptoms (OCS) during their life. To characterize the genetic underpinnings of
OCS and its genetic relationship to OCD, we conducted the largest genome-wide
association study (GWAS) meta-analysis of parent-or self-reported OCS to date (N= 33,943
with complete phenotypic and genome-wide data), combining the results from seven large …
compulsive disorder (OCD), many more (~ 13–38%) experience subclinical obsessive-
compulsive symptoms (OCS) during their life. To characterize the genetic underpinnings of
OCS and its genetic relationship to OCD, we conducted the largest genome-wide
association study (GWAS) meta-analysis of parent-or self-reported OCS to date (N= 33,943
with complete phenotypic and genome-wide data), combining the results from seven large …