… However, the challenge with profiling 5hmC is that it typically … can be used for downstream
genome-wide or targeted 5hmC … better indication of the fragment profile and concentration. A …

… A study involving genome-wide methylation revealed an … in the present study rather than
osteoarthritis [48]. Genotyping … Given the critical effect of LGR6 in regulating bone metabolism, …

… , as genome-wide … reveal a unique skeletal dysplasia phenotype in mice with loss of
Dot1L in limb mesenchyme, highlighting the importance of Dot1L in the developing long bones…

… disease‐modifying drugs to treat osteoarthritis; (iii) … Genome‐wide association study of bone
mineral density in the UK Biobank study identifies over 376 loci associated with osteoporosis…

… early diagnosis of bone diseases, including osteoporosis, osteoarthritis, and bone cancers,
… and explore the association of altered ncRNA expression with stem cells and bone turnover. …

… cells, MSC genes are differentially methylated at 5mC in their … The genome-wide histone
PTM landscape requires constantly … cause of bone loss in people with osteoporosis. Reduced …

… skeletal diseases and disorders, including but not limited to osteoporosis, osteoarthritis, …
In addition, accumulating evidence reveals that miRNAs play crucial roles in regulating key …

… femoral neck bone mineral … of skeletal changes associated with ageing, the ability of
epigenetic clocks to predict future musculoskeletal phenotypes and identify novel loci of methylation …

… However, when dead bone pieces are recreated, the bone is … shows primary osteoblasts
growing from a piece of bone in a … OA was studied by the genome-wide associated scan (GWAS)…

… Overall, our findings revealed an innovative epigenetic … d The expression profiles of genes
in chondrocytes with or without … mechanical forces and skeletal epigenetic changes, which …