[HTML][HTML] NELL-1 in genome-wide association studies across human diseases

X Cheng, J Shi, Z Jia, P Ha, C Soo, K Ting… - The American Journal of …, 2022 - Elsevier
… of NELL1 in diseases and treatments revealed by GWASs. … NELL-1 has therapeutic potential
in osteoarthritis due to its pro-… Osteoporosis is an aging-related bone-degenerative disease …

Revealing novel genomic insights and therapeutic targets for juvenile idiopathic arthritis through omics

J Fan, X Li, J Yang, S Zhang, HQ Qu, D Ji… - …, 2024 - academic.oup.com
… Results: Fourteen genome-wide significant non-HLA loci … JIA and bone mineral density (BMD)
traits at 52 genomic regions, … In this study, we identified four novel genome-wide significant …

The crucial mechanism and therapeutic implication of RNA methylation in bone pathophysiology

C Yang, Z Dong, Z Ling, Y Chen - Ageing Research Reviews, 2022 - Elsevier
bone diseases include a variety of diseases such as osteoporosis (OP), osteoarthritis (OA), …
The opposite function of IGF2BPs to YTHDF2 shows the core functions of reader proteins in …

[HTML][HTML] Epigenetic modifications in spinal ligament aging

Q Xiang, Y Zhao, J Lin, S Jiang, W Li - Ageing Research Reviews, 2022 - Elsevier
… as osteoporosis and osteoarthritis (Marini et al., 2016). And increasing studies investigating
genome-wide or gene-specific methylation profiles … There were 550 differentially methylated

[HTML][HTML] Skeletal aging and osteoporosis: mechanisms and therapeutics

A Chandra, J Rajawat - International journal of molecular sciences, 2021 - mdpi.com
… to a senescence profile in an aged skeleton and how bone … A genome-wide methylation
analysis among osteoporotic … post-menopausal osteoporosis and osteoarthritis, with superior …

[HTML][HTML] Epigenetic regulation of skeletal tissue integrity and osteoporosis development

YS Chen, WS Lian, CW Kuo, HJ Ke, SY Wang… - International Journal of …, 2020 - mdpi.com
… delays chondrocyte loss and cartilage erosion during osteoarthritis development [34]. While
… with genome-wide analyses revealed that rs11614913T in the MIR196A2 gene in bone

[HTML][HTML] Epigenetic regulation of bone remodeling and its role in the pathogenesis of primary osteoporosis

BI Yalaev, RI Khusainova - Vavilov Journal of Genetics and …, 2023 - ncbi.nlm.nih.gov
… studies based on the genome-wide association search (… osteoporotic femoral neck fractures
and osteoarthritis (OA) of the hip … Differential methylation analysis revealed that the upstream …

Mapping 5-hydroxymethylcytosine (5hmC) modifications in skeletal tissues using high-throughput sequencing

FC Grandi, N Bhutani - Osteoporosis and Osteoarthritis, 2021 - Springer
… However, the challenge with profiling 5hmC is that it typically … can be used for downstream
genome-wide or targeted 5hmC … better indication of the fragment profile and concentration. A …

[HTML][HTML] Impact of environmental and epigenetic changes on mesenchymal stem cells during aging

N Smith, S Shirazi, D Cakouros, S Gronthos - International Journal of …, 2023 - mdpi.com
skeletal diseases such as osteoporosis and osteoarthritis, … It was revealed that Bmncr
upregulates the extracellular … that DNA methylation was altered in a genome-wide manner in …

[HTML][HTML] Comprehensive analysis of epigenetics mechanisms in osteoporosis

Y Chen, Y Sun, X Xue, H Ma - Frontiers in Genetics, 2023 - frontiersin.org
Osteoporosis is a metabolic disorder that bones become more … There are now genome-wide
association studies (GWAS) … This research revealed a notable augmentation in the SOST …