[HTML][HTML] Mediation analysis supports a causal relationship between maternal hyperglycemia and placental DNA methylation variations at the leptin gene locus and …

V Gagné-Ouellet, E Breton, K Thibeault… - International journal of …, 2020 - mdpi.com
… as the first 5 principal components as it was sufficient to bring genomic inflation close to 1 [28].
… made it possible to document the potential temporal stability of the reported DNAm marks

DNA methylation as a mediator of associations between the environment and chronic diseases: A scoping review on application of mediation analysis

R Fujii, S Sato, Y Tsuboi, A Cardenas, K Suzuki - Epigenetics, 2022 - Taylor & Francis
… epidemiological research applying mediation analyses. We … for the mediation analysis
using DNAm levels. However, we found heterogenous methods and interpretations in mediation

Genetic variation influencing DNA methylation provides insights into molecular mechanisms regulating genomic function

JS Hawe, R Wilson, KT Schmid, L Zhou… - Nature …, 2022 - nature.com
… We first carried out a genome-wide association study (GWAS) of DNA methylation in peripheral
blood, … Our results thus identify UBASH3B as a potential mediator of both genetic and …

[HTML][HTML] Genetic impacts on DNA methylation: research findings and future perspectives

S Villicaña, JT Bell - Genome biology, 2021 - Springer
… However, growing evidence now shows that genetic variation also plays a role in the
establishment of DNA methylation marks, independently of or in contribution with environmental …

[HTML][HTML] DNA methylation and regulation of gene expression: Guardian of our health

GA Dhar, S Saha, P Mitra, R Nag Chaudhuri - The Nucleus, 2021 - Springer
… , the DNA methylation pattern in the genome undergoes … a stable epigenetic mark, DNA
methylation is actually labile … by vitamin intake other than through mediation by DNMTs or TETs? …

[HTML][HTML] DNA methylation: a potential mediator between air pollution and metabolic syndrome

P Poursafa, Z Kamali, E Fraszczyk, HM Boezen… - Clinical …, 2022 - Springer
… , we found that DNA methylation in neonatal blood is genome-wide significantly associated
… Studying these epigenetic marks together with their interplay with non-protein coding RNA …

[HTML][HTML] Role of DNA methylation in mediating genetic risk of psychiatric disorders

A Starnawska, D Demontis - Frontiers in Psychiatry, 2021 - frontiersin.org
genome to mediate the risk of psychiatric disorders. The aim of this review is to explore the
putative role of DNA methylation … regulatory regions, epigenetic marks, and genes important …

Making it or breaking it: DNA methylation and genome integrity

A Sriraman, TK Debnath, B Xhemalce… - Essays in …, 2020 - portlandpress.com
… of DNA methylation in maintaining genome integrity in mammalian cells. DNA methylation is
a reversible epigenetic mark… DNMTs mediate the transfer of the labile methyl group (–CH 3 ) …

DNA methylation as a mediator in the association between prenatal maternal stress and child mental health outcomes: Current state of knowledge

N Azar, L Booij - Journal of Affective Disorders, 2022 - Elsevier
DNA methylation of the NR3C1 gene. Youth mental health problems were also related to
NR3C1 hypermethylation … and did not detect significant mediation by DNA methylation though …

[HTML][HTML] DNA methylation mediates the effect of maternal smoking on offspring birthweight: a birth cohort study of multi-ethnic US mother–newborn pairs

R Xu, X Hong, B Zhang, W Huang, W Hou, G Wang… - Clinical …, 2021 - Springer
… by multiple epigenetic marks or on a genome-wide scale. As … of mediation and whether
it is causal although our mediation … of 38 differentially methylated CpG sites with genome-wide …