Pseudomonas aeruginosa core metabolism exerts a widespread growth-independent control on virulence

S Panayidou, K Georgiades, T Christofi, S Tamana… - Scientific Reports, 2020 - nature.com
… offering optimized performance for pan-genome analyses. We used a local … Combinatorial
functional transcriptomics analysis at the pathway level was much more informative, revealing

Combining antibiotics with antivirulence compounds can have synergistic effects and reverse selection for antibiotic resistance in Pseudomonas aeruginosa

C Rezzoagli, M Archetti, I Mignot, M Baumgartner… - PLoS …, 2020 - journals.plos.org
… As the combination treatments affect both growth and virulence factor production… combination
with ciprofloxacin and meropenem, where in both cases our sequencing analysis revealed

Roles of Two-Component Systems in Pseudomonas aeruginosa Virulence

M Sultan, R Arya, KK Kim - International journal of molecular sciences, 2021 - mdpi.com
aeruginosa infection and further develop new antibiotics to treat this pathogen. This review
discusses the important virulence factors of P. aeruginosa and the understanding of their …

Parallel evolutionary paths to produce more than one Pseudomonas aeruginosa biofilm phenotype

JG Thöming, J Tomasch, M Preusse, M Koska… - npj Biofilms and …, 2020 - nature.com
virulence phenotypes of a plethora of phylogenetically diverse clinical isolates of the opportunistic
pathogen Pseudomonas aeruginosa… enrichment analysis of upregulated genes shows

Virulence Constitution of Multi-Drug-Resistant Pseudomonas aeruginosa in Upper Egypt

NA Hassuna, SA Mandour… - Infection and drug …, 2020 - Taylor & Francis
aeruginosa showing a combination of adhesion and cytotoxicity … This study revealed
intermediate diversity of ERIC fingerprints, with 2 major clusters (1 and 2) enclosing 22 isolates, …

Virulence Factors of Pseudomonas Aeruginosa and Antivirulence Strategies to Combat Its Drug Resistance

C Liao, X Huang, Q Wang, D Yao, W Lu - … in cellular and infection …, 2022 - frontiersin.org
virulence while sparing the bacterium for its eventual elimination by the immune system, or
combination … The arrows indicate a stimulatory effect, while the perpendicular line indicates

Pseudomonas aeruginosa: a clinical and genomics update

…, C Mirande, A Oliver, P Moons… - FEMS Microbiology …, 2021 - academic.oup.com
… can infect most human organs and does so with virulence. In combination with MDR such
infections are troublesome to treat and present a menace to susceptible patient populations. …

Hypermutator Pseudomonas aeruginosa exploits multiple genetic pathways to develop multidrug resistance during long-term infections in the airways of cystic fibrosis …

CA Colque, AG Albarracín Orio, S Feliziani… - Antimicrobial agents …, 2020 - Am Soc Microbiol
… This indicates that these mutations were positively selected … occur in CF patient sputum
and promote the virulence of P. … AmpC, in which the combination of distinct mutations may …

[HTML][HTML] Genetic determinants of Pseudomonas aeruginosa fitness during biofilm growth

S Schinner, F Engelhardt, M Preusse, JG Thöming… - Biofilm, 2020 - Elsevier
… Advancing knowledge on P. aeruginosa adaptation to biofilm growth conditions is bound to
reveal novel strategies and targets for the treatment of chronic biofilm-associated infections. …

Pseudomonas aeruginosa reference strains PAO1 and PA14: A genomic, phenotypic, and therapeutic review

A Grace, R Sahu, DR Owen, VA Dennis - Frontiers in Microbiology, 2022 - frontiersin.org
… of two pathogenicity islands PAPI-1 and PAPI-2 in the genome of PA14. … is aerobic or
anaerobic, or a combination of both. … A number of studies have revealed genetic and phenotypic …