… Lifetime risk of HCM, defined as the percent chance of a diagnosis of hypertrophic
cardiomyopathy … from MGB Biobank with high-quality genotyping-array and clinical data (eMethods …

… life expectancy to … disease-causing sarcomere variant, leading potentially to both prevention
and exacerbation of the clinical phenotype. In the current study, male sex and genotype (…

… of genetic associations, the need to manage the genotype‐negative HCM patient in a coherent
… relevant to our understanding of other cardiomyopathies and inherited cardiac diseases. …

… cardiac sarcomere genes were first associated with the pathogenesis of hypertrophic
cardiomyopathy (… the relationship between genotype and clinical outcome in this complex disease. …

… reasonable expectation for normal or extended longevity [1]. … years ago – that offered insights
into HCM prevalence was the … may be required for genotype positive individuals to develop …

… lower left ventricular mass, but greater basal septal hypertrophy, with reduced life span (mean
follow-up, 9.9 years) compared with genotype negative individuals (hazard ratio, 2.66 [95…

… inclusion in reference cohorts and insufficient genotyping of black patients with HCM. Thus,
… This study adds insight into the disease experience of HCM in black patients. Black patients …

… Hypertrophic cardiomyopathy (HCM) in children is rare and may present at any age, but …
Genotype and lifetime burden of disease in hypertrophic cardiomyopathy: Insights from the …

… Hypertrophic cardiomyopathy (HCM) is the most common inherited cardiomyopathy and
is … However, the genotype‐phenotype relationship in HCM is incompletely understood and …

… who is genotype positive will develop HCM in their lifetime. If … mechanistic insights questioning
whether LV hypertrophy is … have been reported in genotype positive/phenotype negative …