Innovative animal model of DSS-induced ulcerative colitis in pseudo germ-free mice

S Gancarcikova, S Lauko, G Hrckova, Z Andrejcakova… - Cells, 2020 - mdpi.com
… The antibiotic-treated or pseudo germ-free (PFG) miceexposed to the highest concentration
of DSS (AM5) we detected a significant positive correlation between DAI and the epithelial

Beneficial Effect of Faecal Microbiota Transplantation on Mild, Moderate and Severe Dextran Sodium Sulphate-Induced Ulcerative Colitis in a Pseudo Germ-Free …

S Lauko, S Gancarcikova, G Hrckova, V Hajduckova… - Biomedicines, 2023 - mdpi.com
… 18 mice) control group without induction of ulcerative colitis and … with the mechanism of
epithelial damage, particularly if the … group DSS-FMT exposed to 5% DSS revealed considerable …

Human-derived bacterial strains mitigate colitis via modulating gut microbiota and repairing intestinal barrier function in mice

J Dai, M Jiang, X Wang, T Lang, L Wan, J Wang - BMC microbiology, 2024 - Springer
… develop colitis, while germ-free mice exhibit minimal or no … ameliorate the symptoms of
ulcerative colitis, we firstly isolated … were totally abolished in antibiotic-treated mice, as indicated …

Antibiotics damage the colonic mucus barrier in a microbiota-independent manner

J Sawaed, L Zelik, Y Levin, R Feeney, M Naama… - bioRxiv, 2024 - biorxiv.org
antibiotic-treated mice, as above. In this experimental setup, the SPF mice are exposed to the
antibiotic, while the germ-free mice are … (DSS)-induced colitis. We reasoned that this is the …

Transplant of microbiota from Crohn's disease patients to germ-free mice results in colitis

IA Sheikh, J Bianchi-Smak, D Laubitz, G Schiro… - Gut …, 2024 - Taylor & Francis
… (DSS), or in an adoptive T-cell transfer model of colitis. … of CD_L3 mice, as well as at sites
with evident epithelial damage in … by others in GF or antibiotic-treated mice, typically with more …

Gut microbiota shape the inflammatory response in mice with an epithelial defect

R Wang, M Moniruzzaman, KY Wong, P Wiid… - Gut …, 2021 - Taylor & Francis
… By comparing mice in conventional and germ-free conditions, and by in vitro organoid …
Germ-free and antibiotic-treated mice are highly susceptible to epithelial injury in DSS colitis

Gut microbiota-derived propionate regulates the expression of Reg3 mucosal lectins and ameliorates experimental colitis in mice

D Bajic, A Niemann, AK Hillmer… - … Crohn's and Colitis, 2020 - academic.oup.com
… the mouse caecum almost to a level of germ-free [GF] mice that … 16S rRNA analyses from
faeces of antibiotic-treated mice was … after injury, we administered AE to DSS-treated mice and …

Intestinal epithelial AMPK deficiency causes delayed colonic epithelial repair in DSS-induced colitis

S Olivier, H Diounou, C Pochard, L Frechin, E Durieu… - Cells, 2022 - mdpi.com
… To evaluate the impact of AMPK deletion on colonic mucosal injury and epithelial wound
repair after colitis, IEC AMPK KO and WT mice were exposed to 2.5% (w/v) DSS in drinking …

[HTML][HTML] Probiotic cocktail alleviates intestinal inflammation through improving gut microbiota and metabolites in colitis mice

Y Zhu, Y Xu, X Wang, L Rao, X Yan, R Gao… - Frontiers in Cellular …, 2022 - frontiersin.org
… in DSS-induced acute colitis mice. Remarkable differences are observed among healthy …
bacteria may attach to the injured intestinal epithelium, inhibiting commensal microbes to …

[HTML][HTML] Effects of Broad-spectrum Antibiotic Treatment or Germ-free Status on Endurance Performance and Exercise Adaptations in Mice

NT Hutchinson, SS Wang, J Dokhanchi… - Medicine and science …, 2023 - ncbi.nlm.nih.gov
… citrate synthase (CS) enzyme activity and expression of exercise training-sensitive genes. …
We hypothesized that antibiotic-treated and germ-free mice would display attenuated …