Bad to the bone: the effects of therapeutic glucocorticoids on osteoblasts and osteocytes

M Gado, U Baschant, LC Hofbauer… - Frontiers in …, 2022 - frontiersin.org
… doses of glucocorticoids decreases bone mass … of glucocorticoid receptors across all skeletal
cell populations and their respective progenitors, therapeutic glucocorticoids affect skeletal

The impact of high dose glucocorticoids on bone health and fracture risk in systemic vasculitides

CD Box, O Cronin, B Hauser - Frontiers in Endocrinology, 2022 - frontiersin.org
glucocorticoid or combination treatments. This review will outline the known mechanism of
bone loss … Osteoporosis treatment with specific consideration for patients with vasculitis will be …

Endogenous glucocorticoid metabolism in bone: friend or foe

CS Martin, MS Cooper, RS Hardy - Frontiers in Endocrinology, 2021 - frontiersin.org
corticosteroids are able to enter bone cells. Here 11β-HSD1 can further activate and amplify
the actions of corticosteroidsbone metabolism in osteoclasts, osteocytes and osteoblasts. …

The role of glucocorticoids in inflammatory diseases

SD Reichardt, A Amouret, C Muzzi, S Vettorazzi… - Cells, 2021 - mdpi.com
… For more than 70 years, glucocorticoids (GCs) have been a powerful and affordable
treatment option for inflammatory diseases. However, their benefits do not come without a cost, …

Distinct glucocorticoid receptor actions in bone homeostasis and bone diseases

S Lee, BT Krüger, A Ignatius… - Frontiers in …, 2022 - frontiersin.org
… itself hamper bone integrity. GC signaling is also important for fracture healing and rheumatoid
… This review summarizes the complexity of GC actions via GR in bone cells at cellular and …

The effect of acknowledged and novel anti-rheumatic therapies on periodontal tissues—a narrative review

MA Martu, GA Maftei, I Luchian, OM Stefanescu… - Pharmaceuticals, 2021 - mdpi.com
… has been demonstrated to diminish rheumatic diseasecorticosteroids on a group of
patients with chronic obstructive pulmonary disease concluded that this therapy may affect bone

Steroids in Lupus: Enemies or Allies

E Enríquez-Merayo, MJ Cuadrado - Journal of Clinical Medicine, 2023 - mdpi.com
Glucocorticoids are the gold standard treatment for reducing immune activation and
inflammation in a wide range of inflammatory and systemic autoimmune diseases. Glucocorticoids

[HTML][HTML] An overview of glucocorticoid-induced osteoporosis

I Ilias, C Milionis, E Zoumakis - Endotext [Internet], 2022 - ncbi.nlm.nih.gov
… risk have been presented that take into account glucocorticoid dosage for the Fracture Risk
… GCs are administered; bone loss is more rapid in the first months of therapy. Patients on GCs …

When to start and stop bone-protecting medication for preventing glucocorticoid-induced osteoporosis

KN Hayes, U Baschant, B Hauser, AM Burden… - Frontiers in …, 2021 - frontiersin.org
… % of US patients with chronic conditions warranting glucocorticoid exposure received any
… studies of glucocorticoid effects on bone cell function have been recently published (39, 43). …

Endocrine Disorders in Autoimmune Rheumatological Diseases: A Focus on Thyroid Autoimmune Diseases and on the Effects of Chronic Glucocorticoid Treatment

F Egalini, M Parasiliti Caprino, G Gaggero, V Cappiello… - Endocrines, 2021 - mdpi.com
… Moreover, as glucocorticoids still represent a leading treatment for systemic … rheumatological
diseases, our secondary aim is to summarize the main effects of glucocorticoids treatment …