Emerging connections between oxidative stress, defective proteolysis, and metabolic diseases

T Homma, J Fujii - Free radical research, 2020 - Taylor & Francis
… delivers aggresomes to the growing autophagosomes for … oxidative stress is directly involved
in autophagy dysfunction. … complex and inhibits the late stage of autophagy that occurs at …

Role of mitochondrial dysfunction, oxidative stress and autophagy in progression of Alzheimer's disease

V Bhatia, S Sharma - Journal of the neurological sciences, 2021 - Elsevier
… of cell constituents including proteasomes, aggresomes, and dysfunctional mitochondria as
… (tau protein phosphatase) stimulates neuronal autophagy, thus it providing a relationship …

[HTML][HTML] Complex interplay between autophagy and oxidative stress in the development of pulmonary disease

W Ornatowski, Q Lu, M Yegambaram, AE Garcia… - Redox biology, 2020 - Elsevier
… of autophagy. Current research suggests a central role for autophagy as a mammalian
oxidative stress response and its interrelationship to other stress defense systems. Altered …

[HTML][HTML] Interplay between reactive oxygen species and autophagy in the course of age-related macular degeneration

M Nita, A Grzybowski - EXCLI journal, 2020 - ncbi.nlm.nih.gov
formation of protein aggregates (aggresomes), induces inflammatory cascades in aging RPE
cells, and leads to oxidative stress-… oxidative stress, lipofuscin accumulation, stimulate RPE …

[HTML][HTML] Ubiquitination-proteasome system (UPS) and autophagy two main protein degradation machineries in response to cell stress

Y Li, S Li, H Wu - Cells, 2022 - mdpi.com
… of proteasome or oxidative stress leads to autophagy as an … leads to a compensatory
stimulation of autophagy, whereas … protein aggregation and aggresome formation, which inhibit …

A chemical genomics-aggrephagy integrated method studying functional analysis of autophagy inducers

T Kataura, E Tashiro, S Nishikawa, K Shibahara… - Autophagy, 2021 - Taylor & Francis
… , we examined whether MAP2 K inhibition stimulates autophagy. As shown in Figure 5D,…
glucose deprivation, a process that causes oxidative stress and stimulates aggresome formation

[HTML][HTML] Promiscuous roles of autophagy and proteasome in neurodegenerative proteinopathies

F Limanaqi, F Biagioni, S Gambardella… - International journal of …, 2020 - mdpi.com
… misfolded proteins to the aggresome, where autophagy is recruited [… with an increase in
oxidative stress along with a marked … as well as autophagy/mitophagy stimulation, was recently …

Lysosomal dysfunction–induced autophagic stress in diabetic kidney disease

HJ Zheng, X Zhang, J Guo, W Zhang… - Journal of cellular …, 2020 - Wiley Online Library
… aggrephagy (protein aggresomes), … autophagy induction under mild oxidative stress
stimulation seems to act primarily as a pro-survival mechanism to protect against oxidative damage

How autophagy can restore proteostasis defects in multiple diseases?

V Joshi, A Upadhyay, VK Prajapati… - Medicinal Research …, 2020 - Wiley Online Library
Oxidative stress in plants activates autophagy that helps in … in autophagy functions give
rise to oxidative stress in normal … mTOR and in turn inhibits autophagy induction. The tumor …

Impaired Vps34 complex activity-mediated autophagy inhibition contributes to endothelial progenitor cells damage in the ischemic conditions

R Jiang, X Zhang, Q Zhang, X Zheng, H Shi… - Biochemical and …, 2020 - Elsevier
… 1C); p62/aggresomes, presenting autophagic substrate … that autophagy is downregulated
in the OGD-stimulated EPCs, … factors such as oxidative stress and inflammation are involved. …