Cocaine, amphetamine, and methamphetamine abuse disorders are serious worldwide
health problems. To date, there are no FDA-approved medications for the treatment of these
disorders. Elucidation of the biochemical underpinnings contributing to psychostimulant
addiction is critical for the development of effective therapies. Excitatory signaling and
glutamate homeostasis are well known pathophysiological substrates underlying addiction-
related behaviors spanning multiple types of psychostimulants. To alleviate relapse …