The Phosphorylation of Kv1. 3: A Modulatory Mechanism for a Multifunctional Ion Channel

M Navarro-Pérez, I Estadella, A Benavente-Garcia… - Cancers, 2023 - mdpi.com
… In this scenario, some channels, such as Kv2.1, present with high basal … Overall, the
regulation of ion channels via phosphorylation is exceptionally complex and variable. Some Kv …

Protein kinase C controls the excitability of cortical pyramidal neurons by regulating Kv2. 2 channel activity

Z Li, W Dong, X Zhang, JM Lu, YA Mei, C Hu - Neuroscience Bulletin, 2022 - Springer
… of Kv2.2 is also dependent on its phosphorylation state … we investigated whether Kv2.2
channels can be phosphorylated by … of ion channel regulation by phosphorylation which changes …

Kv2. 1 potassium channels regulate repetitive burst firing in extratelencephalic neocortical pyramidal neurons

GS Newkirk, D Guan, N Dembrow… - Cerebral …, 2022 - academic.oup.com
… outward currents that regulate bursting. We tested whether Kv2 channels regulate the f ADP
and burst firing in labeled layer 5 PNs from motor cortex of the Thy1-h mouse. Kv2 block with …

Kv2.1 channels play opposing roles in regulating membrane potential, Ca2+ channel function, and myogenic tone in arterial smooth muscle

SC O'Dwyer, S Palacio, C Matsumoto… - Proceedings of the …, 2020 - National Acad Sciences
… −/− myocytes are similar to those observed with varying degrees of Ca V 1.2 … role for Kv2.1
channels is as an ion channel regulating … and phosphorylation of the plasma membrane Kv2.1

Tyrosine Phosphorylation of the Kv2.1 Channel Contributes to Injury in Brain Ischemia

MY Song, JY Hwang, EJ Bae, S Kim, HM Kang… - International Journal of …, 2020 - mdpi.com
… that can help clarify whether tyrosine phosphorylation of K v 2.1 can regulate the channel
clustering in the plasma membrane. … K v 2.1 Voltage-dependent potassium channel K v 2.1 …

Electrophysiological Analysis of Kv2 Channel Regulation by Non-Canonical and Canonical Mechanisms

EE Maverick - 2020 - search.proquest.com
ion channel structure and function and led to our current … and S800, whose phospho-states
regulate the Kv2.1 current surge. It … They found variable effects of each mutation on channel

[HTML][HTML] Cleavage of Kv2. 1 by BACE1 decreases potassium current and reduces neuronal apoptosis

Q Sun, F Liu, J Zhao, P Wang, X Sun - Neurochemistry International, 2022 - Elsevier
Kv2.1, a potassium channel, modulates potassium current in … These data clearly testified
that BACE1 regulated Kv2.1 I … Kv2.1 phosphorylation affects channel gating and cellular …

Tunable action potential repolarization governed by Kv3. 4 channels in dorsal root ganglion neurons

TD Alexander, T Muqeem, L Zhi… - Journal of …, 2022 - Soc Neuroscience
… the expression and effective phosphorylation status of the … potassium channel to manipulate
its expression and effective … reflect variable basal PKC-dependent phosphorylation of still-…

Sites and Regulation of L-Type Ca2+ Channel Cav1.2 Phosphorylation in Brain

SK Shin, HY Li, K Cho, YW Cho, JH Lee… - Cellular and Molecular …, 2022 - Springer
regulation by phosphorylation have been reported in heart and muscles. Here, we identified
phosphorylation sites of neuronal Ca v 1.2 channel … of these phosphorylation sites showed …

Increased KV2.1 Channel Clustering Underlies the Reduction of Delayed Rectifier K+ Currents in Hippocampal Neurons of the Tg2576 Alzheimer's Disease Mouse

I Piccialli, MJ Sisalli, V de Rosa, F Boscia, V Tedeschi… - Cells, 2022 - mdpi.com
phosphorylation as they display numerous phosphorylation … The control for the specificity of
the antibody against K V 2.1 … and the involvement of potassium channels in these processes. …