How are granulocytes for transfusion best used? The past, the present and the future

S Morton, K Fleming… - British Journal of …, 2023 - Wiley Online Library
… of refractory infection in the setting of severe neutropenia. There … for apheresis granulocytes
with G-CSF and/or steroid use … that granulocyte transfusions have a role in immune priming, …

How do we… consistently provide high‐dose granulocyte products for transfusions in neutropenic patients?

R Bubar, JE Kiss, DJ Triulzi, P D'Andrea, A Zilich… - …, 2023 - Wiley Online Library
… Here we describe the collection process and granulocyte product … The inlet and return lines
are primed according to … been pre-treated with steroids. Our practice has experience with …

Use of granulocyte transfusion in early period in life-threatening infections of pediatric hematology and oncology patients: A single-center experience

BS Koc, F Tekkesin, UM Yıldırım, SC Kılıc - Transfusion and Apheresis …, 2021 - Elsevier
infections along with severe neutropenia. The patients who had … The obtained granulocyte
concentrate was immediately … , antihistaminic and steroid before transfusion. It is also …

[HTML][HTML] Granulocyte transfusions

Q Lu - UpToDate, 2022 - medilib.ir
Since these infections are the direct result of neutropenia, granulocyte transfusion (GTX) as
… To increase the number of granulocytes collected by apheresis, corticosteroids were used …

Granulocyte transfusion vs. neutropenia—is there a chance to win this battle?

A Szumowski, PM Radziwon - Medical Research Journal, 2022 - journals.viamedica.pl
… Nowadays, granulocytes are collected from related or unrelated donors after priming
them with a combination of G-CSF and corticosteroids [15]. Furthermore, even though the …

[HTML][HTML] Comparison of Neutrophil Function in Granulocyte Concentrates From Prednisone-and G-CSF-Treated Donors: Effect of Stimulant, Leukapheresis and …

A Murru, MÈ Allard, G Paré, M Vaillancourt… - Frontiers in …, 2022 - frontiersin.org
… of prednisone and G-CSF GC neutrophils prior to and after … the isolated neutrophils
harvested from prednisone GCs after 24 h … is suggestive of neutrophil priming during storage. …

frontiers ORIGINAL RESEARCH in Medicine published: 04 March 2022 doi: 10.3389/fmed. 2022.839475

…, DR Branch, M Girard, CF Prednisone… - … new motifs in …, 2023 - books.google.com
… of prednisone and G-CSF GC neutrophils prior to and after … the isolated neutrophils
harvested from prednisone GCs after 24 h … is suggestive of neutrophil priming during storage. …

Chronic neutropenia: how best to assess severity and approach management?

J Donadieu, S Frenz, L Merz… - Expert Review of …, 2021 - Taylor & Francis
… of Granulocyte-Colony Stimulating factor (GCSF) in chronic … Demargination tests (physical
exertion, corticosteroids, … context of its discovery and collecting some key information on the …

Transfusable neutrophil progenitors as cellular therapy for the prevention of invasive fungal infections

DB Sykes, MM Martinelli, P Negoro, S Xu… - Journal of leukocyte …, 2022 - academic.oup.com
… (granulocyte) transfusions for the treatment of neutropenic … In these trials, donors are typically
treated with corticosteroids and/… The collected neutrophils are transfused immediately into …

Targeting multiple cell death pathways extends the shelf life and preserves the function of human and mouse neutrophils for transfusion

Y Fan, Y Teng, F Loison, A Pang, A Kasorn… - Science translational …, 2021 - science.org
… Large doses of neutrophils can now be easily obtained from … –treated neutrophils after their
transfusion to neutropenic hosts (… of neutrophils in the granulocyte apheresis concentrates …