… FGF-23, produced by osteoblasts and osteocytes in response … of Cyp2r1 and Cyp27b1 in the
rat brain tissue in females … and the expression of IGFBP-3 protein is positively regulated, but …

… by osteocytes, mature osteoblasts that grow to be embedded … range of tissues and
cells including osteoblasts [11] and is a … IGFBP-3; and serum controlled Parallel. regimen (placebo). …

… During this process, chondrocytes in the growth plate differentiate through different stages
and finally undergo apoptosis or transdifferentiate into osteoblasts [1, 2]. In humans, growth …

… -pituitary-growth hormone axis Energy deficiency results in a state of growth hormone (GH) …
GH stimulates osteoblast precursors and mature osteoblasts both directly and indirectly …

… hormones [7]. Increased production of osteoclasts and decreased production of osteoblasts
… Understanding the molecular signals that regulate osteoclasts and osteoblasts is essential …

… Proliferating osteoblasts respond by stimulating microvessel formation by expressing VEGF-…
with the IGFBP-3 DNA plasmid, followed by implantation of the construct in the rat mandibles …

… An in vitro study uncovered that fetal rats treated with PHT exhibited an impaired
osteoblastic response to PTH[23], suggesting the drug directly modulates bone metabolism. In …

… regulation of osteoblast proliferation and differentiation [48]. … influenced by both sex steroids
and growth hormone [68]. Thus, … -3 (IGFBP-2 or IGFBP-3) are reported in studies in children …

Introduction Long-term treatment with antiepileptic drugs may cause secondary osteoporosis.
The present study investigated the influence of simvastatin (SIM) in reversing the effects of …

… evidence of growth hormone (GH) … -1 and IGFBP-3 blood levels were significantly lower
than those in age-matched controls, and these findings could also be modeled in the juvenile rat …