[HTML][HTML] Multiple sclerosis: doubling down on MHC
… For multiple sclerosis (MS), an autoimmune disease that affects the brain and spinal cord, an
association with the HLA-DR15 haplotype … that large pieces of 6p21 encompassing multiple …
association with the HLA-DR15 haplotype … that large pieces of 6p21 encompassing multiple …
Epstein Barr virus infection and immune defense related to HLA‐DR15: consequences for multiple sclerosis
T Olsson - European Journal of Immunology, 2021 - Wiley Online Library
… higher viral load in HLA-DR15 + haplotype bearing immune … The potential role of EBV in
MS has recently been reviewed … Further support comes from large-scale genetic epidemiology …
MS has recently been reviewed … Further support comes from large-scale genetic epidemiology …
Genetics and familial distribution of multiple sclerosis: A review
A Balcerac, C Louapre - Revue Neurologique, 2022 - Elsevier
… reviews the genetics of multiple sclerosis (MS), as well as intra-familial concordance and
clinical correlations between different members of a family. Indeed, significant … of a haplotype, ie…
clinical correlations between different members of a family. Indeed, significant … of a haplotype, ie…
[HTML][HTML] Macrophages and HLA-Class II Alleles in Multiple Sclerosis: Insights in Therapeutic Dynamics
P Prapas, M Anagnostouli - International Journal of Molecular Sciences, 2024 - mdpi.com
… This narrative review aims to comprehensively describe the … The effect of the HLA haplotype
in the drug effectiveness and … that HLA-DR15 positive humanized mice exhibited significant …
in the drug effectiveness and … that HLA-DR15 positive humanized mice exhibited significant …
[HTML][HTML] High resolution haplotype analyses of classical HLA genes in families with multiple sclerosis highlights the role of HLA-DP alleles in disease susceptibility
K Osoegawa, LE Creary, G Montero-Martín… - Frontiers in …, 2021 - frontiersin.org
… for the extended families but reviewed the HLA allele/haplotype inheritance patterns
within the … We did not find statistically significant protective effects mediated by the HLA-DRB1*01:01:…
within the … We did not find statistically significant protective effects mediated by the HLA-DRB1*01:01:…
High‐resolution HLA class II sequencing of Swedish multiple sclerosis patients
O Akel, LP Zhao, DE Geraghty… - International Journal of …, 2022 - Wiley Online Library
… of the discussion section, significant haplotypes are presented as … in MS included the
HLA-DR15-DQ6 haplotype together with … We thank Åke Lernmark for the critical review of the …
HLA-DR15-DQ6 haplotype together with … We thank Åke Lernmark for the critical review of the …
[HTML][HTML] Clinical and genetic analysis in pediatric patients with multiple sclerosis and related conditions: focus on DR genes of the major histocompatibility complex
A Galym, N Akhmetova… - The Open …, 2022 - openneurologyjournal.com
… The HLA-DR15 haplotype genes were detected in 3 out of 7 children and in 4 out of 14 … in
a wide range of disciplines. The papers published are of high quality after rigorous peer review …
a wide range of disciplines. The papers published are of high quality after rigorous peer review …
HLA-DRB1*15:01 and the MERTK Gene Interact to Selectively Influence the Profile of MERTK-Expressing Monocytes in Both Health and MS
MD Binder, EC Nwoke, E Morwitch… - Neurology …, 2023 - AAN Enterprises
… MERTK are 2 risk genes for multiple sclerosis (MS). The variant … underlying the DR15
haplotype–associated decrease in … CD14 + MERTK+ monocytes in HLA-DR15–positive patients, …
haplotype–associated decrease in … CD14 + MERTK+ monocytes in HLA-DR15–positive patients, …
[HTML][HTML] Immune-mediated genesis of multiple sclerosis
S Cavallo - Journal of Translational Autoimmunity, 2020 - Elsevier
… the disease to specific HLA haplotypes. Moreover, a wide range of evidence supports the
fact … as in “humanized” HLA-DR15-Tg mice; HLA-DQ6-restricted, but not HLA-DR15-restricted, …
fact … as in “humanized” HLA-DR15-Tg mice; HLA-DQ6-restricted, but not HLA-DR15-restricted, …
The Genetics of Multiple Sclerosis
AE Miner, N Dastgheyb, M Palomino… - … : Multiple Sclerosis …, 2021 - Springer
… A Human Genome Epidemiology (HuGE) review examined … between 1993 and 2004; the
review found that in all but a … 03:01 haplotypes: differential contribution to multiple sclerosis …
review found that in all but a … 03:01 haplotypes: differential contribution to multiple sclerosis …