HMGB1: an overview of its versatile roles in the pathogenesis of colorectal cancer

KJ Cheng, MA Alshawsh, EH Mejia Mohamed… - Cellular Oncology, 2020 - Springer
… Additionally, it should be considered whether there are other pathways mediating HMGB1-induced
responses in CRC. We believe that this is certainly possible as it is known that …

[HTML][HTML] Oncogenic role of HMGB1 as an alarming in robust prediction of immunotherapy response in colorectal cancer

H Lu, M Zhu, L Qu, H Shao, R Zhang, Y Li - Cancers, 2022 - mdpi.com
HMGB1 in 33 types of cancer through the TCGA, GEO, and Oncomine databases. We found
that HMGB1 may function in the regulation of cancer … in HMGB1 is related with both clinical …

Differential characteristics of HMGB2 versus HMGB1 and their perspectives in ovary and prostate cancer

M Cámara-Quílez, A Barreiro-Alonso… - Current Medicinal …, 2020 - ingentaconnect.com
… and differences between HMGB1 and HMGB2 expression, … about HMGB1 and HMGB2
functions and expression, as well as … p53) silencing of both p53 and HMGB1 is necessary to get …

[HTML][HTML] Subcellular localization of HMGB1 in colorectal cancer impacts on tumor grade and survival prognosis

CQ Wang, BF Huang, Y Wang, CH Tang, HC Jin… - Scientific reports, 2020 - nature.com
… in colorectal cancer (CRC). We found significantly higher rates of nuclear HMGB1 expression
… This is the first time that HMGB1 has been found to play both positive and negative roles in …

Impact of HMGB1 on cancer development and therapeutic insights focused on CNS malignancy

S Patra, PK Roy, A Dey, M Mandal - … Acta (BBA)-Reviews on Cancer, 2024 - Elsevier
… Henceforth, our review discusses the bidirectional impact of HMGB1, acting as both a
promoter of tumor progression and a mediator of anti-tumor immune responses. Notably, …

The redox protein HMGB1 in cell death and cancer

R Chen, J Zou, R Kang, D Tang - Antioxidants and Redox Signaling, 2023 - liebertpub.com
… This receptor diversity can be defined in part by posttranslational modifications of HMGB1
and interactions of HMGB1 with other immune-activating molecules, including DNA, RNA, …

[HTML][HTML] HMGB1, the next predictor of transcatheter arterial chemoembolization for liver metastasis of colorectal cancer?

Y Sun, H Zhang, Y Chen, C Wu, J Zhang, H Xu… - … in Oncology, 2020 - frontiersin.org
… changes of HMGB1 in the serum of colorectal cancer patients with … TACE by monitoring the
changes of HMGB1. In this study, we … Induced by extracellular HMGB1 and other inflammatory …

[HTML][HTML] Roles of HMGB1 in regulating myeloid-derived suppressor cells in the tumor microenvironment

S Jin, Z Yang, X Hao, W Tang, W Ma, H Zong - Biomarker Research, 2020 - Springer
… In addition, resveratrol-treated Lewis lung cancer cells express less HMGB1 and induce lower
levels … Other in vitro studies with autophagy inhibitors and HMGB1 inhibitors indicated that …

[HTML][HTML] Complement system and alarmin HMGB1 crosstalk: for better or worse

C Gaboriaud, M Lorvellec, V Rossi… - Frontiers in …, 2022 - frontiersin.org
… and HMGB1 could likely play a key role in several other severe disease contexts, in
particular inflammatory diseases where the immune pathology is host-driven, including cancer, …

[HTML][HTML] Role of HMGB1 and its associated signaling pathways in human malignancies

S Idoudi, T Bedhiafi, S Pedersen, M Elahtem… - Cellular …, 2023 - Elsevier
… In light of the recent growing evidence linking HMGB1 to cancer progression, we think that it
may … Moreover, hemorrhagic shock or other stimuli can also trigger HMGB1 release [21]. For …