Head and neck tumors angiogenesis imaging with 68Ga-NODAGA-RGD in comparison to 18F-FDG PET/CT: a pilot study
S Durante, V Dunet, F Gorostidi, P Mitsakis… - EJNMMI research, 2020 - Springer
S Durante, V Dunet, F Gorostidi, P Mitsakis, N Schaefer, J Delage, JO Prior
EJNMMI research, 2020•SpringerBackground Angiogenesis plays an important role in head and neck squamous cell
carcinoma (HNSCC) progression. This pilot study was designed to compare the distribution
of 68 Ga-NODAGA-RGD PET/CT for imaging α v β 3 integrins involved in tumor
angiogenesis to 18 F-FDG PET/CT in patients with HNSCC. Material and methods Ten
patients (aged 58.4±8.3 years [range, 44–73 years], 6 males, 4 females) with a total of 11
HNSCC were prospectively enrolled. Activity mapping and standard uptake values (SUV) …
carcinoma (HNSCC) progression. This pilot study was designed to compare the distribution
of 68 Ga-NODAGA-RGD PET/CT for imaging α v β 3 integrins involved in tumor
angiogenesis to 18 F-FDG PET/CT in patients with HNSCC. Material and methods Ten
patients (aged 58.4±8.3 years [range, 44–73 years], 6 males, 4 females) with a total of 11
HNSCC were prospectively enrolled. Activity mapping and standard uptake values (SUV) …
Background
Angiogenesis plays an important role in head and neck squamous cell carcinoma (HNSCC) progression. This pilot study was designed to compare the distribution of 68Ga-NODAGA-RGD PET/CT for imaging αvβ3 integrins involved in tumor angiogenesis to 18F-FDG PET/CT in patients with HNSCC.
Material and methods
Ten patients (aged 58.4 ± 8.3 years [range, 44–73 years], 6 males, 4 females) with a total of 11 HNSCC were prospectively enrolled. Activity mapping and standard uptake values (SUV) from both 68Ga-NODAGA-RGD and 18F-FDG PET/CT scans were recorded for primary tumor and compared with the Wilcoxon signed-rank test. The relation between the SUV of both tracers was assessed using the Spearman correlation.
Results
All HNSCC tumors were visible with both tracers. Quantitative analysis showed higher 18F-FDG SUVmax in comparison to 68Ga-NODAGA-RGD (14.0 ± 6.1 versus 3.9 ± 1.1 g/mL, p = 0.0017) and SUVmean (8.2 ± 3.1 versus 2.0 ± 0.8 g/mL, p = 0.0017). Both 18F-FDG and 68Ga-NODAGA-RGD uptakes were neither correlated with grade, HPV status nor p16 protein expression (p ≥ 0.17).
Conclusion
All HNSCC tumors were detected with both tracers with higher uptake with 18F-FDG, however. 68Ga-NODAGA-RGD has a different spatial distribution than 18F-FDG bringing different tumor information.
Trial registration
NCT, NCT02666547. Registered 12.8.2012.
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