Retinoid metabolism and functions mediated by retinoid binding-proteins

JL Napoli, HS Yoo - Methods in enzymology, 2020 - Elsevier
retinoids in the aqueous cellular medium, and allow retinoid … In extra-hepatic tissues, Crbp1
sequesters retinol transferred into … Isolation of retinoids from the cellular milieu within Crbp1 (…

Retinoid homeostasis and beyond: how retinol binding protein 4 contributes to health and disease

JS Steinhoff, A Lass, M Schupp - Nutrients, 2022 - mdpi.com
distribute hepatic vitamin A stores to extrahepatic tissues. In particular, binding of RBP4 to
‘stimulated by retinoic … crystal structure of human retinol-free RBP4 isolated from serum, urine, …

Biochemistry and pharmacology of retinoids

WS Blaner - Retinoids in oncology, 2020 - taylorfrancis.com
… Specific binding proteins for both retinol and retinoic acid have … in hepatic retinoid metabolism,
the question of how retinoid … and binding proteins in isolated rat liver cells. J Biol Chem …

[HTML][HTML] Impaired hepatic vitamin A metabolism in NAFLD mice leading to vitamin A accumulation in hepatocytes

A Saeed, P Bartuzi, J Heegsma, D Dekker… - Cellular and molecular …, 2021 - Elsevier
Hepatic retinol and retinol binding protein 4 (RBP4) levels were … (C) Freshly isolated and
4-hour attached primary rat … hepatic levels of the various retinoids (retinyl esters, retinol

The molecular aspects of absorption and metabolism of carotenoids and retinoids in vertebrates

MAK Widjaja-Adhi, M Golczak - … et Biophysica Acta (BBA)-Molecular and …, 2020 - Elsevier
… numerous specialized retinoid-transport proteins, receptors, and enzymes. … hepatic pool of
retinoids requires the hydrolysis of REs, transport of ROL back to the hepatocytes, and binding

Retinol-binding protein 2 (RBP2): biology and pathobiology

WS Blaner, PJ Brun, RM Calderon… - Critical reviews in …, 2020 - Taylor & Francis
… than retinol, retinaldehyde, or retinoic acid (see Ligand binding … The increase in hepatic
Rbp2 expression upon pregnancy was … Studies of isolated DCs have identified that granulocyte-…

Changes in retinoid metabolism and signaling associated with metabolic remodeling during fasting and in type I diabetes

AV Klyuyeva, OV Belyaeva, KR Goggans… - Journal of Biological …, 2021 - ASBMB
… The bioactive derivative of vitamin A, retinoic acid (RA), was … the dynamics of hepatic retinoid
metabolism and signaling in … qPCR analysis was performed using mRNA isolated from the …

Retinol-binding protein-4 and nonalcoholic fatty liver disease

H Huang, C Xu - Chinese Medical Journal, 2022 - journals.lww.com
… [8] Since its first isolation from the human serum in 1968, … Stimulated-by-retinoic acid-6
(STRA6) is the specific receptor … to the related metabolic enzymes. [18] STRA6 is expressed in the …

[HTML][HTML] The role of the retinoid receptor, RAR/RXR heterodimer, in liver physiology

B Li, SY Cai, JL Boyer - Biochimica et Biophysica Acta (BBA)-Molecular …, 2021 - Elsevier
… ) is the rate-limiting enzyme in bile acid synthesis. The … in freshly isolated rat HSC where
treatment with retinoids decreased … relate to hepatic lipid metabolism, bile acid metabolism and …

Impact of vitamin A transport and storage on intestinal retinoid homeostasis and functions

M Honarbakhsh, A Ericsson, G Zhong… - Journal of lipid …, 2021 - ASBMB
… In the fasting state, the delivery of VA to extrahepatic … retinol (ROH) bound to retinol-binding
protein (RBP or RBP4) upon its secretion from the liver, the major body reserve of retinoids ( …