… in the field of memory CD8 + T-cell differentiation, and we will … basis of CD8 + T lymphocyte
heterogeneity, the timing of cell fate decisions, and the epigenetic networks controlling T-cell …

… highlights how heterogeneity of T cell responses can propagate from variation in expression
of a single chemokine receptor or subtle cell positioning all the way to differentiation fate. …

… ), has the potential to differentiate into long-lived memory CD8 T (Tmem) cells. Some SLECs
… suggested to regulate early Teff cell differentiation and Teff versus Tmem cell fate decisions. …

… commitment of effector vs memory CD8 + T cell subsets have … Although the mechanisms of
CD8 + T cell fate decision have … the heterogeneity of numerous constellation of T cell subsets, …

… regulation of effector and memory CD8 + T-cell fate determination, … , activated CD8 + T cells
form a heterogeneous effector … CD8 + T cells acquire a terminally differentiated effector state …

… Stem-cell-like features of central memory CD8 T cells. (A) A single naive precursor … As
we have highlighted in this review, single T-cell fate mapping in vivo has provided us with rich …

… phase exhibit substantial phenotypic heterogeneity, which correlates with different potentials
for terminal differentiation or developing into specific memory CD8 T-cell subclasses during …

… central memory CD8 + T cell precursors proliferate more slowly than terminally differentiating
effector CD8 + T cell… T cell fate, including memory development, has not been continuously …

… Inter-clonal and intra-clonal functional heterogeneity of effector and memory CD4 + T cell
subsets have also been described in response to viral, bacterial and fungal antigens [3]. …

… either die or form memory CD8 + T cells during the contraction … the heterogeneity in marker
distributions for different naïve CD8 + T cell families, they showed that a linear differentiation …