[HTML][HTML] Advances in smoking cessation pharmacotherapy: Non-nicotinic approaches in animal models

LC Smith, O George - Neuropharmacology, 2020 - ncbi.nlm.nih.gov
… pathway and show efficacy in reducing nicotine addiction-like … , higher oxidation, and
inflammation that are associated with … primates (Table 6). The majority of preclinical work on anti-…

Reinforcing and adverse observable effects of nicotine and minor tobacco alkaloids in squirrel monkeys

EL Burke, RI Desai - Drug and Alcohol Dependence, 2024 - Elsevier
… Given the lack of information available on the behavioral pharmacology of minor tobacco
alkaloids alone in a primate species, as a first step we sought to test several prominent minor …

[HTML][HTML] Behavioral and neuronal extracellular vesicle biomarkers associated with nicotine's enhancement of the reinforcing strength of cocaine in female and male …

MI Allen, BN Johnson, A Kumar, Y Su, S Singh… - Addiction …, 2024 - Elsevier
… was to examine, in nonhuman primate models, the effects of co-use of nicotine on the …
models of reinforcing strength (or efficacy). Two of the more frequently used schedules of …

Effects of chronic treatment with bupropion on self-administration of nicotine+ cocaine mixtures in nonhuman primates.

FB de Moura, CE Barkin, BE Blough… - Experimental and …, 2020 - psycnet.apa.org
nicotine to augment the reinforcing effects of cocaine. However, the mechanism of action of
nicotine … in bupropion’s effectiveness to attenuate the reinforcing effects of nicotine + cocaine …

Self-administration of inhaled delta-9-tetrahydrocannabinol and synthetic cannabinoids in non-human primates.

ZD Cooper, SM Evans, RW Foltin - Experimental and clinical …, 2021 - psycnet.apa.org
… products in non-human primates (NHPs). Results point to minimal reinforcing effects of …
the hypothesis that higher-efficacy CB1 receptor agonists are more reinforcing than partial …

Translational value of non-human primates in opioid research

H Ding, MC Ko - Experimental neurology, 2021 - Elsevier
… from experiencing reinforcing effects … , nicotinic receptor agonist, monoclonal antibodies
with high affinities for opioids, have been studied in rodents to show potential effectiveness in …

Safety and immunogenicity of the anti-cocaine vaccine UFMG-VAC-V4N2 in a non-human primate model

B Sabato, PS de Almeida Augusto, RLG Pereira… - Vaccine, 2023 - Elsevier
… Maurer et al., in 2005, investigated the safety of the Nicotine-Qb … The efficacy and safety of
a nicotine conjugate vaccine (… Penicillata species, a non-human primate model. This species …

Evaluation of the reinforcing strength of phendimetrazine using a progressive-ratio schedule of reinforcement in rhesus monkeys

M Minkiewicz, PW Czoty, BE Blough… - Journal of Pharmacology …, 2020 - ASPET
… in a standard primate chair (Primate Products). … reinforcing at LH20), with no change in
the number of saline injections delivered. Interestingly, however, the maximum effectiveness of …

Cognitive-enhancing effects of acetylcholine receptor agonists in group-housed cynomolgus monkeys who drink ethanol

LK Galbo-Thomma, PM Epperly, BE Blough… - … of Pharmacology and …, 2024 - ASPET
… In the present study, the procognitive efficacy of two AChR … response to a change in
reinforcement contingencies. The ability … agonist xanomeline and the nicotinic ACh receptor …

GDNF gene therapy for alcohol use disorder in male non-human primates

MM Ford, BE George, VS Van Laar, KM Holleran… - Nature medicine, 2023 - nature.com
… We examined the utility and efficacy of delivering AAV2 … or presence of the nicotinic
acetylcholine receptor antagonist DHβE (… a fixed schedule of food reinforcement in which a pellet …