Safety and efficacy of MD1003 (high-dose biotin) in patients with progressive multiple sclerosis (SPI2): a randomised, double-blind, placebo-controlled, phase 3 trial
… sclerosis” for clinical trials of disease-modifying treatments in both primary progressive
and secondary progressive multiple sclerosis and studies of high-dose biotin and relevant …
and secondary progressive multiple sclerosis and studies of high-dose biotin and relevant …
[HTML][HTML] The rise and fall of high-dose biotin to treat progressive multiple sclerosis
CH Goldschmidt, JA Cohen - Neurotherapeutics, 2020 - Springer
… Breakthrough disease under high-dose biotin in progressive multiple sclerosis. European
Comittee on Treatment and Research in Multiple Sclerosis Annual Conference; Paris: …
Comittee on Treatment and Research in Multiple Sclerosis Annual Conference; Paris: …
High-dose biotin for multiple sclerosis: A systematic review and meta-analyses of randomized controlled trials
AI Espiritu, PPM Remalante-Rayco - Multiple Sclerosis and Related …, 2021 - Elsevier
… enhance the production of adenosine triphosphate (ATP), which may be … and safety of
high-dose biotin (HDB) in multiple sclerosis via a … Secondary progressive multiple sclerosis …
high-dose biotin (HDB) in multiple sclerosis via a … Secondary progressive multiple sclerosis …
High-dose biotin in multiple sclerosis: the end of the road
J Motte, R Gold - The Lancet Neurology, 2020 - thelancet.com
… The trial randomly assigned 642 participants with primary or secondary progressive multiple
sclerosis (297 [46%] men and 345 [54%] women) either MD1003 (n=326) or placebo (n=316…
sclerosis (297 [46%] men and 345 [54%] women) either MD1003 (n=326) or placebo (n=316…
[HTML][HTML] Relapses during high-dose biotin treatment in progressive multiple sclerosis: a case-crossover and propensity score-adjusted prospective cohort
P Branger, JJ Parienti, N Derache, N Kassis… - …, 2020 - Springer
… High-dose biotin (HDB) is a therapy used in non-active progressive multiple sclerosis (PMS).
Some reports have suggested that HDB treatment may be associated with an increased …
Some reports have suggested that HDB treatment may be associated with an increased …
High-dose biotin in progressive multiple sclerosis: A prospective study of 178 patients in routine clinical practice
L Couloume, L Barbin, E Leray… - Multiple Sclerosis …, 2020 - journals.sagepub.com
… Patients with primary progressive MS (PPMS) or secondary progressive MS (SPMS) who …
high-dose biotin treatment was started. However, 12 months into the high-dose biotin treatment…
high-dose biotin treatment was started. However, 12 months into the high-dose biotin treatment…
Biomarkers of treatment response in patients with progressive multiple sclerosis treated with high‐dose pharmaceutical‐grade biotin (MD1003)
… The role of the secondary progressive form in treatment response should be interpreted with
caution according to the large credibility interval (OR 0.42; 95% CI [0.07; 1.27]). Normalized …
caution according to the large credibility interval (OR 0.42; 95% CI [0.07; 1.27]). Normalized …
Supplementary medication in multiple sclerosis: real-world experience and potential interference with neurofilament light chain measurement
K Pape, F Steffen, F Zipp… - Multiple Sclerosis Journal …, 2020 - journals.sagepub.com
… progressive MS and 9 patients with secondary progressive MS… Patients opposed to standard
disease-modifying drugs and … -based, such as high-dose biotin, may not be referred to a …
disease-modifying drugs and … -based, such as high-dose biotin, may not be referred to a …
[HTML][HTML] High-dose biotin neither fosters remyelination nor stimulates malonyl coenzyme A synthesis in the regenerating nerve
F Szepanowski, RD Steubing, C Güngör… - Neural Regeneration …, 2023 - journals.lww.com
… regenerative therapy in multiple sclerosis, the concept of high-dose biotin (HDB) treatment
(… of HDB in patients with primary and secondary progressive MS revealed promising results (…
(… of HDB in patients with primary and secondary progressive MS revealed promising results (…
[HTML][HTML] Novel drugs in a pipeline for progressive multiple sclerosis
K Sapko, A Jamroz-Wiśniewska, K Rejdak - Journal of Clinical Medicine, 2022 - mdpi.com
… while taking biotin, the results of the study excluded the possibility of an increased risk of
relapses during biotin therapy [23]. In preliminary studies, high-dose biotin was considered a …
relapses during biotin therapy [23]. In preliminary studies, high-dose biotin was considered a …