A novel promising frontier for human health: The beneficial effects of nutraceuticals in cardiovascular diseases

A Carrizzo, C Izzo, M Forte, E Sommella… - International Journal of …, 2020 - mdpi.com
… , placebo-controlled clinical trials showed a decreased expression of … a reduction of insulin
resistance with an improvement of insulin sensitivity and beta-… IRS insulin receptor substrate

Phytochemicals as potential epidrugs in type 2 diabetes mellitus

K Ramirez-Alarcon, M Victoriano, L Mardones… - Frontiers in …, 2021 - frontiersin.org
… involved in lipid metabolism, substrate transport and inflammatory … In this study, the 11β-HSD1
activity by resveratrol was … studies, 500 mg of leaf extract improved insulin resistance

Effects of resveratrol supplementation on nitric oxide-mediated vascular outcomes in hypertension: A systematic review

JC DiNatale, KM Crowe-White - Nitric Oxide, 2022 - Elsevier
… role of RESV on BP in human clinical trials is conflicting. For example, … Additionally, two
studies with overweight and obese … Finally, in a study of men with metabolic syndrome, 16 weeks …

Insights into the Therapeutic and Pharmacological Properties of Resveratrol as a Nutraceutical Antioxidant Polyphenol in Health Promotion and Disease Prevention

S Mohammadi, MD Moghadam… - … Reviews in Clinical …, 2024 - ingentaconnect.com
… 4CL with coenzyme A as a co-substrate. pCoumaroyl-CoA is … Insulin resistance is usually
found in obese people with high … Therefore, high-dose consumption of Resveratrol (use of 5 g …

Novel nutraceuticals to tackle brain and muscle bioenergetics

SM Ostojic - Clinical Bioenergetics, 2021 - Elsevier
… Another randomized placebo-controlled trial in patients with … fatty liver disease and insulin
resistance (NCT02216552). … of 6-month high-dose B-group vitamin supplementation on …

Resveratrol and other natural oligomeric stilbenoid compounds and their therapeutic applications

CG Duta-Bratu, GM Nitulescu, DP Mihai, OT Olaru - Plants, 2023 - mdpi.com
… In a placebo-controlled trial, both grape extract and grape … with a moderate to high dose of
resveratrol (1 g/day) may help … positive effects concerning insulin resistance in obesity. This …

[PDF][PDF] Therapeutic potential and epigenetic alterations of plant phytochemicals (as epi-drugs) for the treatment of type 2 diabetes mellitus: a systematic review

KK Kaur, G Allahbadia, M Singh - Adv. Obes. Weight Manag …, 2021 - researchgate.net
… the time of enhancement of insulin sensitivity.The maximum … implicated in lipid metabolism,
substrate transfer along with … larger double blind randomized, placebo controlled trials are …

Stilbenes: Beneficial Effects of Resveratrol Metabolites in Obesity, Dyslipidemia, Insulin Resistance, and Inflammation

I Eseberri, I Milton‐Laskibar… - … : Their Metabolism …, 2020 - Wiley Online Library
High-dose resveratrol supplementation in obese men: an investigator-initiated, randomized,
placebo-controlled … , and body composition. Diabetes, 62, 1186–95. Rayalam, S., Yang, JY, …

Therapeutic potential of select dietary compounds in the management of hypertension and its cardiovascular complications

AF Valookaran, J Bouchard, BM Aloud, SJ Thandapilly… - Molecules, 2022 - mdpi.com
… a high dose of quercetin aglycone (1095 mg) to 17 overweight, … blind, placebo-controlled,
randomized clinical trial, researchers … The effect of resveratrol in 11 obese men aged 52.5 ± 2.1 …

Adipogenesis as a potential anti-obesity target: A review of pharmacological treatment and natural products

J Jakab, B Miškić, Š Mikšić, B Juranić… - Diabetes, metabolic …, 2021 - Taylor & Francis
… of the triad of over-weight/obesity, insulin resistance (IR), and … Citation129 In studies using
3T3-L1 cells, resveratrol treatment … sensitivity, blood pressure, and body composition. Citation…