… Therefore, we hypothesized that Se-SAHA was effective at suppressing autophagy and …
is a novel pan-HDAC inhibitor for the treatment of cardiac hypertrophy and fibrosis during …

… –131), decreasing overactive autophagy (132), and upregulating … related signaling pathways
are suppressed, and cardiac … and briefly introduce therapeutic HDAC inhibition (Figure 1). …

… , and regulation of apoptosis, autophagy, and cell cycle arrest. … cardiac hypertrophy,
hypertension, myocardial infarction, … , leading to the suppression of cardiac hypertrophy induced …

… cardiomyocyte autophagy and suppressed NLRP3 … Unlike other HDACs, histone deacetylase
6 (HDAC6) contains … cardiomyocyte autophagy, thereby attenuating ventricular remodeling …

… Histone acetylation is a reversible modification status … through activation of autophagy,
inhibition of acetylation, suppression of … HDAC inhibitors have been extensively explored for their …

… induced cardiac hypertrophy by suppressing autophagic activation.… Histone deacetylases 1
and 2 regulate autophagy flux and … Histone deacetylase (HDAC) inhibitors attenuate cardiac …

… Finally, we discuss the application of HDAC inhibitors in heart … Mechanistically, Sirt3 could
reduce cardiac hypertrophy by … PPARα, thereby suppressing FA utilization in the failing heart. (…

… known to inhibit class IIa histone deacetylases (HDACs) [14,15… IIa HDACs prevent cardiac
hypertrophy by the suppression … elicited cardiac hypertrophy [18], or by attenuating autophagy …

… The use of valproic acid led to attenuated cardiac hypertrophy and fibrosis in these rats. …
-inflammatory and antifibrotic effects is the suppression of profibrotic factors (TGFβ, fibronectin, …

… and are pan-HDAC inhibitors that inhibit all classic HDACs. MS275/… conditions involving
cardiac hypertrophy, myocardial infarction (MI… While miR-21-3p suppressed cardiac hypertrophy, …