[HTML][HTML] Effects of Sirt3‑autophagy and resveratrol activation on myocardial hypertrophy and energy metabolism
HN Wang, JL Li, T Xu, HQ Yao… - Molecular medicine …, 2020 - spandidos-publications.com
… histone deacetylase (HDAC) III (8). As a nicotinamide adenine dinucleotide (NAD)-dependent
HDAC … promote fatty acid oxidation in myocardial cells, reduce the anaerobic glycolysis of …
HDAC … promote fatty acid oxidation in myocardial cells, reduce the anaerobic glycolysis of …
Systemic study of selected histone deacetylase inhibitors in cardiac complications associated with cancer cachexia
… promising results by attenuating the cardiac complications, … HDAC produces beneficial
effect on cardiac hypertrophy. The … that different classes of HDAC inhibitors (HDACi) may have …
effect on cardiac hypertrophy. The … that different classes of HDAC inhibitors (HDACi) may have …
Therapeutic Potential of HDAC Inhibitors in the Treatment of Cardiac Diseases: A Short Review
V Tiwari, SK Banerjee - Current Drug Targets, 2023 - ingentaconnect.com
… The long-term suppression of cardiac hypertrophy is linked … Histone deacetylase adaptation
in single ventricle heart disease and a young animal model of right ventricular hypertrophy. …
in single ventricle heart disease and a young animal model of right ventricular hypertrophy. …
[HTML][HTML] Histone deacetylase HDAC4 participates in the pathological process of myocardial ischemia-reperfusion injury via MEKK1/JNK pathway by binding to miR …
Q Li, L Zhu, F Niu, Q Li, C Wang, H Yang, C Gao - Cell Death Discovery, 2021 - nature.com
… suppression of MEKK1 and JNK can also confer protective effects against cardiac hypertrophy
and heart … revealed the potential cardioprotective benefits of HDAC inhibitors in MIRI [27, …
and heart … revealed the potential cardioprotective benefits of HDAC inhibitors in MIRI [27, …
HDAC inhibition reverses preexisting diastolic dysfunction and blocks covert extracellular matrix remodeling
… Inhibition of histone deacetylases (HDACs) has been shown … K, LV weight-to-tibia length
measurements of cardiac hypertrophy. … showed that HDAC inhibitors suppress cardiac fibroblast …
measurements of cardiac hypertrophy. … showed that HDAC inhibitors suppress cardiac fibroblast …
Emerging epigenetic therapies of cardiac fibrosis and remodelling in heart failure: from basic mechanisms to early clinical development
… a histone deacetylase-3 (HDAC-3)-mediated mechanism. … ) 76 and attenuated cardiac
hypertrophy in mice subjected to … SAHA include an increase in autophagic flux, improved myofibril …
hypertrophy in mice subjected to … SAHA include an increase in autophagic flux, improved myofibril …
[HTML][HTML] Downregulation of P300/CBP-associated factor attenuates myocardial ischemia-reperfusion injury via inhibiting autophagy
L Qiu, C Xu, H Xia, J Chen, H Liu… - International Journal of …, 2020 - ncbi.nlm.nih.gov
… autophagy is unknown yet. Hence, this study was to investigate whether downregulation
of PCAF attenuate MIRI by inhibiting autophagy. … that inhibition of excessive autophagy by …
of PCAF attenuate MIRI by inhibiting autophagy. … that inhibition of excessive autophagy by …
Peptidase inhibitor 16 attenuates left ventricular injury and remodeling after myocardial infarction by inhibiting the HDAC1‐Wnt3a‐β‐Catenin signaling axis
L Wang, A Du, Y Lu, Y Zhao, M Qiu, Z Su… - … of the American Heart …, 2023 - Am Heart Assoc
… HDAC (class I histone deacetylase) is a key protein that … ), which are markers of cardiac
hypertrophy, were decreased in PI16… suppresses the Wnt/β‐catenin pathway mainly by inhibiting …
hypertrophy, were decreased in PI16… suppresses the Wnt/β‐catenin pathway mainly by inhibiting …
Silencing EIF3A ameliorates pulmonary arterial hypertension through HDAC1 and PTEN/PI3K/AKT pathway in vitro and in vivo
HT Yang, G Wang, PC Zhu, ZY Xiao - Experimental Cell Research, 2023 - Elsevier
… and right ventricular hypertrophy and suppressed MCT-… level, we here identified histone
deacetylases 1 (HDAC1) as … dysfunction through its effects on cell proliferation and autophagy …
deacetylases 1 (HDAC1) as … dysfunction through its effects on cell proliferation and autophagy …
Protein acetylation in cardiac aging
A Francois, A Canella, LM Marcho… - … and cellular cardiology, 2021 - Elsevier
… Histone acetylation is a critical mechanism for regulation of … regulation of autophagy was
linked to the acetylation state of … lead to cardiac hypertrophy, fibrosis and cardiac dysfunction. In …
linked to the acetylation state of … lead to cardiac hypertrophy, fibrosis and cardiac dysfunction. In …