Melatonin alleviates cardiac dysfunction via increasing sirt1-mediated beclin-1 deacetylation and autophagy during sepsis
QZ Pi, XW Wang, ZL Jian, D Chen, C Zhang, QC Wu - Inflammation, 2021 - Springer
… of Beclin-1 suppressed autophagy in the heart, thus leading … 430 and 437 via inhibiting histone
deacetylase (HDAC) classes I… study demonstrated that autophagy was attenuated after 24 …
deacetylase (HDAC) classes I… study demonstrated that autophagy was attenuated after 24 …
TGF-β1/SMAD3 Regulates Programmed Cell Death 5 That Suppresses Cardiac Fibrosis Post–Myocardial Infarction by Inhibiting HDAC3
L Weng, J Ye, F Yang, S Jia, M Leng, B Jia… - Circulation …, 2023 - Am Heart Assoc
… cardiac dysfunction through HDAC3 (histone deacetylase 3) … -induced cardiac remodeling
in the heart by promoting autophagy … T cells c2 during cardiac hypertrophy, and cardiomyocyte-…
in the heart by promoting autophagy … T cells c2 during cardiac hypertrophy, and cardiomyocyte-…
Targeting histone deacetylases for heart diseases
G Jin, K Wang, Y Zhao, S Yuan, Z He, J Zhang - Bioorganic Chemistry, 2023 - Elsevier
… homeostasis by controlling autophagy and regulating PGC-1α… , CG200745 suppressed the
expression of hypertrophic and … its ability to significantly attenuate cardiac hypertrophy in TAC …
expression of hypertrophic and … its ability to significantly attenuate cardiac hypertrophy in TAC …
Combining three independent pathological stressors induces a heart failure with preserved ejection fraction phenotype
… cardiac phenotype includes cardiac hypertrophy, myocardial … of histone deacetylases (HDACs,
CM hypertrophy regulators) … 4, 5, 7, and 9) are thought to suppress cardiac hypertrophy. …
CM hypertrophy regulators) … 4, 5, 7, and 9) are thought to suppress cardiac hypertrophy. …
Rutin alleviates EndMT by restoring autophagy through inhibiting HDAC1 via PI3K/AKT/mTOR pathway in diabetic kidney disease
R Dong, X Zhang, Y Liu, T Zhao, Z Sun, P Liu, Q Xiang… - Phytomedicine, 2023 - Elsevier
… HDAC1 overexpression was suppressed in HG-induced … of autophagy in HG-induced
GEnCs could attenuate EndMT. … Among these DEPs, we found histone deacetylase 1 (HDAC1) …
GEnCs could attenuate EndMT. … Among these DEPs, we found histone deacetylase 1 (HDAC1) …
Inhibition of lncRNA Gm15834 attenuates autophagy-mediated myocardial hypertrophy via the miR-30b-3p/ULK1 axis in mice
C Song, H Qi, Y Liu, Y Chen, P Shi, S Zhang, J Ren… - Molecular Therapy, 2021 - cell.com
… Inhibition of miR-30b-3p enhanced cardiomyocyte autophagic activity and aggravated
myocardial hypertrophy, … -3p suppressed autophagy-induced myocardial hypertrophy by targeting …
myocardial hypertrophy, … -3p suppressed autophagy-induced myocardial hypertrophy by targeting …
[HTML][HTML] Role of acetylation in doxorubicin-induced cardiotoxicity
D Li, Y Yang, S Wang, X He, M Liu, B Bai, C Tian… - Redox Biology, 2021 - Elsevier
… regulated by histone deacetylases (HDACs) and histone … also suppresses excessive
autophagy through inhibiting … In addition, curcumin ameliorate DOX-mediated cardiac hypertrophy …
autophagy through inhibiting … In addition, curcumin ameliorate DOX-mediated cardiac hypertrophy …
[HTML][HTML] Acetylation in cardiovascular diseases: Molecular mechanisms and clinical implications
… of myocardial I/R injury, possibly through restoring autophagic … )-induced hypertrophy by
regulating histone acetylation on … in the pathophysiological progress of cardiac hypertrophy. …
regulating histone acetylation on … in the pathophysiological progress of cardiac hypertrophy. …
The role and molecular mechanism of epigenetics in cardiac hypertrophy
H Lei, J Hu, K Sun, D Xu - Heart failure reviews, 2021 - Springer
… Therefore, we can deduce that MeCP2 suppression can weaken the … Histone acetylation
and cardiac hypertrophy … -specific HDAC inhibitor, TSA, inhibits cardiac hypertrophy induced by …
and cardiac hypertrophy … -specific HDAC inhibitor, TSA, inhibits cardiac hypertrophy induced by …
Role of histone deacetylase Sirt3 in the development and regression of atherosclerosis
Y Liu, X Shen, M Pang, Z Sun, Y Qian, W Xue, Z Wang… - Life Sciences, 2021 - Elsevier
… ), and avoid myocardial cell dysfunction such as cardiac hypertrophy, … stress and improve
autophagy through its epigenetic … Like Idebenone [95], Ad can suppress ROS production and …
autophagy through its epigenetic … Like Idebenone [95], Ad can suppress ROS production and …