Histone deacetylase inhibitors: a novel strategy for neuroprotection and cardioprotection following ischemia/reperfusion injury
Z Pickell, AM Williams, HB Alam… - Journal of the American …, 2020 - Am Heart Assoc
… I/R injury can induce cellular damage through hypoxic and … SAHA pretreatment of mouse
cardiomyocytes in I/R injury led to … IIb HDAC6 inhibitor Tub‐A on rat cardiomyocytes showed …
cardiomyocytes in I/R injury led to … IIb HDAC6 inhibitor Tub‐A on rat cardiomyocytes showed …
Activation of autophagic flux blunts cardiac ischemia/reperfusion injury
… histone deacetylase) inhibition enhances cardiomyocyte autophagy and blunts ischemia/reperfusion
(I/R) injury … Here, we present evidence that induction of cardiomyocyte autophagy in …
(I/R) injury … Here, we present evidence that induction of cardiomyocyte autophagy in …
Isoform-selective HDAC inhibitor mocetinostat (MGCD0103) alleviates myocardial ischemia/reperfusion injury via mitochondrial protection through the HDACs/CREB …
K Wang, R Tang, S Wang, Y Xiong… - Journal of …, 2022 - journals.lww.com
… inflammatory responses and cardiomyocyte apoptosis. … proapoptotic proteins, eventually
causing cardiomyocyte death 6 and … Treatment of histone deacetylase inhibitors (HDACi) results …
causing cardiomyocyte death 6 and … Treatment of histone deacetylase inhibitors (HDACi) results …
[HTML][HTML] Histone deacetylase HDAC4 participates in the pathological process of myocardial ischemia-reperfusion injury via MEKK1/JNK pathway by binding to miR …
Q Li, L Zhu, F Niu, Q Li, C Wang, H Yang, C Gao - Cell Death Discovery, 2021 - nature.com
… cardiomyocyte apoptosis induced by ischemia-reperfusion (IR), is a crucial cause for myocardial
damage … ) and resuspended using a pipette with the blunt end tip. The tissues were then …
damage … ) and resuspended using a pipette with the blunt end tip. The tissues were then …
[HTML][HTML] The histone deacetylase inhibitor SAHA exerts a protective effect against myocardial ischemia/reperfusion injury by inhibiting sodium-calcium exchanger
X Shi, Y Yin, X Guo, M Liu, F Ma, L Tian… - Biochemical and …, 2023 - Elsevier
… of cardiomyocytes. Suberoylanilide hydroxamic acid (SAHA), a small molecule histone
deacetylases inhibitor … by promoting the opening of mPTP, causing cardiomyocyte mortality and …
deacetylases inhibitor … by promoting the opening of mPTP, causing cardiomyocyte mortality and …
Role of epigenetic regulation in myocardial ischemia/reperfusion injury
K Wang, Y Li, T Qiang, J Chen, X Wang - Pharmacological Research, 2021 - Elsevier
… I/R and cardiomyocyte hypoxia/reoxygenation (H/R)-induced … well known for inhibiting the
activity of histone deacetylases. … -103/107 was involved in inhibiting cardiomyocyte necrosis by …
activity of histone deacetylases. … -103/107 was involved in inhibiting cardiomyocyte necrosis by …
A novel histone deacetylase inhibitor Se-SAHA attenuates isoproterenol-induced heart failure via antioxidative stress and autophagy inhibition
T Cheng, C Liu, Y Wang, G Li, L Feng, S Zhang… - Toxicology and Applied …, 2024 - Elsevier
… in myocardial ischemia/reperfusion injury and Takotsubo-like myocardial injury (Khurana et
… Se-SAHA effectively reduced the ISO-induced increase in cardiomyocyte size, as shown by …
… Se-SAHA effectively reduced the ISO-induced increase in cardiomyocyte size, as shown by …
The protective role of Bmal1-regulated autophagy mediated by HDAC3/SIRT1 pathway in myocardial ischemia/reperfusion injury of diabetic rats
Z Qiu, H Ming, Y Zhang, Y Yu, S Lei, Z Xia - Cardiovascular drugs and …, 2021 - Springer
… 1 (SIRT1) are histone deacetylases that regulate important … To measure the autophagic flux
in H9c2 cardiomyocytes, we … attenuated H/R-induced injury by activating autophagy levels …
in H9c2 cardiomyocytes, we … attenuated H/R-induced injury by activating autophagy levels …
[HTML][HTML] Regulation of metabolism by mitochondrial enzyme acetylation in cardiac ischemia-reperfusion injury
… affect lysine acetylation are known as histone deacetylase … the recovery of the cardiac
myocytes from injury, ostensibly by … likely mitigated ROS-induced damage during reperfusion [85]. …
myocytes from injury, ostensibly by … likely mitigated ROS-induced damage during reperfusion [85]. …
Therapeutic effects of histone deacetylase inhibitors on heart disease
P Chun - Archives of Pharmacal Research, 2020 - Springer
… MEF2 transcription factors are implicated in cardiomyocyte hypertrophy by inducing fetal
genes. Class IIa HDACs have a MEF2-binding domain and two conserved serine residues. …
genes. Class IIa HDACs have a MEF2-binding domain and two conserved serine residues. …