… histone marks and their modifying enzymes. It has to be noted that, although a new nomenclature
for histone-modifying enzymes … The specificity of these enzymes is usually restricted to …

… histone modifications and their associated enzymes. One current viewpoint, based largely
on correlative evidence, posits that histone modifications … ligase with specificity for H2AK119 (…

… the interaction between histones and DNA. The acetylated histone modification affects the
… Therefore, the improvement of HDAC isoform specificity is likely one of the most pressing …

… dual specificity phosphatase 5 … in DNA and histone-modifying enzymes contribute to
human malignant tumors [11], and HDAC are no exception [60]. These enzymes also play an …

… , proline isomerization, and ubiquitination by specific modifying enzymes. But other … activities
operate on a genome-wide basis with minimal specificity for particular chromosomal regions…

… histone deacetylases (Table 1) described elsewhere [9]. We will briefly recapitulate the role
of histones and histone modifications and … We will then describe the specificity of each HDAC …

… However, a general H2A–H2B chaperone cannot explain specificity of variant deposition, …
chromatin-modifying enzymes) and their unique sequence, non-replicative histone variants …

… chromatin-associated proteins known as chromatin-modifying enzymes. These enzymes reside
… , subcellular localization, tissue specificity, and enzymatic activities, they are categorized …

… are used to detect the histone modifications and histone-modifying enzymes in vitro except
… decreased expression of DUSP22 (dual specificity phosphorylase 22 and increased level of …

… a specificity switch within PARPs [[45, 54, 65]], something that is unprecedented in the field
of post-translationally modifying enzymes… instance histones, for the same enzymatic reaction. …