Archaeal chromatin 'slinkies' are inherently dynamic complexes with deflected DNA wrapping pathways

S Bowerman, J Wereszczynski, K Luger - Elife, 2021 - elifesciences.org
… Eukaryotic genomes are orders of magnitude larger and … sacrificing histone-histone or
histone-DNA interactions. Simulations … Arc207 particle shape in comparison to compact Nuc147. …

Archaea: the final frontier of chromatin

SP Laursen, S Bowerman, K Luger - Journal of molecular biology, 2021 - Elsevier
… utilized by various archaea to organize their genomes: histones… histone-histone and
histone-DNA interactions. In contrast, … Because histone chaperones, assembly factors, and ATP-…

[HTML][HTML] Histone variants in archaea–An undiscovered country

KM Stevens, T Warnecke - Seminars in Cell & Developmental Biology, 2023 - Elsevier
… encoded in the same archaeal genome do different things. We … haphazardly, be incorporated
into and shape the properties of a … The dynamic size of histone-DNA complexes and the …

Comparative analysis of genome-wide protein-DNA interactions across domains of life reveals unique binding patterns for hypersaline archaeal histones

S Sakrikar, RK Hackley, M Martinez-Pastor, CL Darnell… - bioRxiv, 2022 - biorxiv.org
… octamer (nucleosome core) and for histone-DNA binding(30). Eukaryotic nucleosomes …
We focused on peak shape and genome-wide binding frequency: it has been observed that …

Histone-organized chromatin in bacteria

A Hocher, SP Laursen, P Radford, J Tyson, C Lambert… - bioRxiv, 2023 - biorxiv.org
… in eukaryotes and most archaea, while bacteria generally rely … In all other known histone-DNA
complexes, DNA is wrapped … represents the subset of genome assemblies that were used …

Histones with an unconventional DNA-binding mode in vitro are major chromatin constituents in the bacterium Bdellovibrio bacteriovorus

A Hocher, SP Laursen, P Radford, J Tyson… - Nature …, 2023 - nature.com
… and organize the genomes of eukaryotes and most archaea, … weight and shape of a
macromolecular assembly. A 147 bp … in nearly all other histoneDNA complexes is missing (Fig. 1c…

Investigating the Biological Role and Binding Modes of Histone-Like Proteins of Halophilic Archaea

S Sakrikar - 2022 - search.proquest.com
… compaction of the genome is a feature found in species across the tree of life. In Archaea,
the … The MNase fragments obtained in-vitro with a recombinant histone-DNA complex were …

The hypersaline archaeal histones HpyA and HstA are DNA binding proteins that defy categorization according to commonly used functional criteria

S Sakrikar, RK Hackley, M Martinez-Pastor, CL Darnell… - Mbio, 2023 - Am Soc Microbiol
histone-DNA interactions (4). A hallmark of histone-based compaction in eukaryotes is their
ubiquitous binding throughout the genome, … shape of binding peaks; percentage of genome

[PDF][PDF] Deep conservation of histone variants in Thermococcales archaea

KM Stevens, A Hocher… - Genome Biology and …, 2022 - academic.oup.com
… Our results support the notion that archaea and eukaryotes have convergently evolved
histone … Histone-DNA assemblies in archaea: shaping the genome on the edge of life. Leiden, …

Bacterial N4-methylcytosine as an epigenetic mark in eukaryotic DNA

F Rodriguez, IA Yushenova, D DiCorpo… - Nature …, 2022 - nature.com
… In bacteria and archaea, DNA modifications are first and foremost … over annotated genomic
features in bona fide eukaryotic contigs. … Components involved in other types of histone/DNA