… Comparing the parent honokiol structure with its four derivatives, we found that HH-A
demonstrated higher pharmacological effects against cerebral ischemia/reperfusion injury, …

… honokiol inhibit the pro-inflammatory response by inhibiting … The P53 tumor suppressor
gene is involved in autophagy … model Protecting the brain against ischaemic reperfusion injury; …

… Another research group found that overexpression of STAT3 pathway endogenous
suppressor protein SOCS3 in astrocytes of AD mice also inhibited astrocyte A1 polarization and …

… of diseased cells, reduction in the expression of defective proteins like P-glycoproteins,
inhibition of oxidative stress, suppression of pro-inflammatory cytokines (TNF-α, IL-10 and IL-6), …

… Thus, we investigated whether honokiol treatment stimulates the Nrf2-mediated transcriptional
… also protects against renal IR injury by increasing SOD and catalase and suppressing …

… Therefore, our results showed that honokiol inhibits the activation of astrocytes rather than
… model or ischemic stroke [24, 34]. We demonstrated that honokiol could suppress the …

… however, honokiol inhibited the apoptotic process at a certain level and might be effective
in the inflammation process. Honokiol has anti-inflammatory activity through inhibition of …

… However, the clear reduction in expressions of caspase-12, cytochrome C, and active
caspase-3 after honokiol treatment strongly suggested that honokiol could suppress apoptosis by …

… injury in mice by inhibiting reactive oxygen … ischemia/reperfusion injury[33] and amyloid-β
oligomer-induced neurotoxicity.[34] Similarly, in the present study, HKL could suppress …

… Honokiol provides cardiac protection from MI/RI by suppressing mitochondrial apoptosis
through the PI3K/… that Honokiol pretreatment can improve cardiac function during MI/RI injury. …