Oxidative damage in sporadic colorectal cancer: molecular mapping of base excision repair glycosylases in colorectal cancer patients
P Vodicka, M Urbanova, P Makovicky… - International Journal of …, 2020 - mdpi.com
… the repair process by … also participate to protect DNA against oxidative damage, such as
NTH1, MTH1, NEIL1-3, XRCC1 and PARP-1 [57,58,59,60]). Another DNA glycosylase involved …
NTH1, MTH1, NEIL1-3, XRCC1 and PARP-1 [57,58,59,60]). Another DNA glycosylase involved …
Impact of oxidative DNA damage and the role of DNA glycosylases in neurological dysfunction
MML de Sousa, J Ye, L Luna, G Hildrestrand… - International Journal of …, 2021 - mdpi.com
… of oxidative DNA base lesions and the role of DNA glycosylase enzymes repairing these …
the role of DNA base oxidation as an epigenetic mechanism involved in brain diseases, as …
the role of DNA base oxidation as an epigenetic mechanism involved in brain diseases, as …
The involvement of nucleotide excision repair proteins in the removal of oxidative DNA damage
N Kumar, S Raja, B Van Houten - Nucleic acids research, 2020 - academic.oup.com
… Moreover, when HeLa cell extracts were incubated with 20 bp cdA substrates, no DNA
glycosylase-mediated cleavage was observed suggesting that human DNA glycosylases cannot …
glycosylase-mediated cleavage was observed suggesting that human DNA glycosylases cannot …
Inhibitors of DNA glycosylases as prospective drugs
GV Mechetin, AV Endutkin, EA Diatlova… - International Journal of …, 2020 - mdpi.com
… systems of antioxidant defense and oxidative damage repair in bacteria are now regarded
… In bacteria, several DNA glycosylases are responsible for oxidative damage repair. In E. coli, …
… In bacteria, several DNA glycosylases are responsible for oxidative damage repair. In E. coli, …
Evolutionary origins of DNA repair pathways: role of oxygen catastrophe in the emergence of DNA glycosylases
… involved in oxidative damage repair, the H2tH glycosylases represent good candidates for
acquisition from symbiotic mitochondria functionally associated with the evolution of oxidative …
acquisition from symbiotic mitochondria functionally associated with the evolution of oxidative …
Focus on dna glycosylases—a set of tightly regulated enzymes with a high potential as anticancer drug targets
F Hans, M Senarisoy, C Bhaskar Naidu… - International journal of …, 2020 - mdpi.com
… can either favor cell transformation, tumorigenesis, and/or drug resistance, or instead
sensitize cells to oxidative damage by enhancing the production of toxic BER products [20]. A …
sensitize cells to oxidative damage by enhancing the production of toxic BER products [20]. A …
DNA glycosylase NEIL2 functions in multiple cellular processes
… As described earlier, we found increased accumulation of oxidative DNA damage with age in
… These observations suggest that oxidative damage in the genome alone is not sufficient for …
… These observations suggest that oxidative damage in the genome alone is not sufficient for …
GO system, a DNA repair pathway to cope with oxidative damage
AV Endutkin, DO Zharkov - Molecular Biology, 2021 - Springer
… It is assumed that the MutY/MUTYH enzymes, in addition to their direct DNA glycosylase
function, can serve as sensors of oxidative stress due to the presence of iron-sulfur clusters ([Fe …
function, can serve as sensors of oxidative stress due to the presence of iron-sulfur clusters ([Fe …
Structural and evolutionary adaptations of Nei‐like DNA glycosylases proteins involved in base excision repair of oxidative DNA damage in vertebrates
… Nei-like DNA glycosylase genes encoding protein that regulate the DNA repair process in
… This study examined the genomic sequences of Nei-like DNA glycosylases in the vertebrate …
… This study examined the genomic sequences of Nei-like DNA glycosylases in the vertebrate …
The Impact of Human DNA Glycosylases on the Activity of DNA Polymerase β toward Various Base Excision Repair Intermediates
AS Bakman, SS Boichenko, AA Kuznetsova… - International Journal of …, 2023 - mdpi.com
… and DNA glycosylases may participate in BER coordination, we decided to study the effects
of various DNA glycosylases on Polβ’s nucleotidyl transferase activity toward different DNA …
of various DNA glycosylases on Polβ’s nucleotidyl transferase activity toward different DNA …