Oxidative damage in sporadic colorectal cancer: molecular mapping of base excision repair glycosylases in colorectal cancer patients

P Vodicka, M Urbanova, P Makovicky… - International Journal of …, 2020 - mdpi.com
… the repair process by … also participate to protect DNA against oxidative damage, such as
NTH1, MTH1, NEIL1-3, XRCC1 and PARP-1 [57,58,59,60]). Another DNA glycosylase involved

Impact of oxidative DNA damage and the role of DNA glycosylases in neurological dysfunction

MML de Sousa, J Ye, L Luna, G Hildrestrand… - International Journal of …, 2021 - mdpi.com
… of oxidative DNA base lesions and the role of DNA glycosylase enzymes repairing these …
the role of DNA base oxidation as an epigenetic mechanism involved in brain diseases, as …

The involvement of nucleotide excision repair proteins in the removal of oxidative DNA damage

N Kumar, S Raja, B Van Houten - Nucleic acids research, 2020 - academic.oup.com
… Moreover, when HeLa cell extracts were incubated with 20 bp cdA substrates, no DNA
glycosylase-mediated cleavage was observed suggesting that human DNA glycosylases cannot …

Inhibitors of DNA glycosylases as prospective drugs

GV Mechetin, AV Endutkin, EA Diatlova… - International Journal of …, 2020 - mdpi.com
… systems of antioxidant defense and oxidative damage repair in bacteria are now regarded
… In bacteria, several DNA glycosylases are responsible for oxidative damage repair. In E. coli, …

Evolutionary origins of DNA repair pathways: role of oxygen catastrophe in the emergence of DNA glycosylases

P Prorok, IR Grin, BT Matkarimov, AA Ishchenko… - Cells, 2021 - mdpi.com
involved in oxidative damage repair, the H2tH glycosylases represent good candidates for
acquisition from symbiotic mitochondria functionally associated with the evolution of oxidative

Focus on dna glycosylases—a set of tightly regulated enzymes with a high potential as anticancer drug targets

F Hans, M Senarisoy, C Bhaskar Naidu… - International journal of …, 2020 - mdpi.com
… can either favor cell transformation, tumorigenesis, and/or drug resistance, or instead
sensitize cells to oxidative damage by enhancing the production of toxic BER products [20]. A …

DNA glycosylase NEIL2 functions in multiple cellular processes

AH Sarker, PK Cooper, TK Hazra - Progress in biophysics and molecular …, 2021 - Elsevier
… As described earlier, we found increased accumulation of oxidative DNA damage with age in
… These observations suggest that oxidative damage in the genome alone is not sufficient for …

GO system, a DNA repair pathway to cope with oxidative damage

AV Endutkin, DO Zharkov - Molecular Biology, 2021 - Springer
… It is assumed that the MutY/MUTYH enzymes, in addition to their direct DNA glycosylase
function, can serve as sensors of oxidative stress due to the presence of iron-sulfur clusters ([Fe …

Structural and evolutionary adaptations of Nei‐like DNA glycosylases proteins involved in base excision repair of oxidative DNA damage in vertebrates

HI Ahmad, G Afzal, S Sadia, G Haider… - Oxidative medicine …, 2022 - Wiley Online Library
… Nei-like DNA glycosylase genes encoding protein that regulate the DNA repair process in
… This study examined the genomic sequences of Nei-like DNA glycosylases in the vertebrate …

The Impact of Human DNA Glycosylases on the Activity of DNA Polymerase β toward Various Base Excision Repair Intermediates

AS Bakman, SS Boichenko, AA Kuznetsova… - International Journal of …, 2023 - mdpi.com
… and DNA glycosylases may participate in BER coordination, we decided to study the effects
of various DNA glycosylases on Polβ’s nucleotidyl transferase activity toward different DNA