Effects of atrial fibrillation on the human ventricle
S Pabel, M Knierim, T Stehle, F Alebrand… - Circulation …, 2022 - Am Heart Assoc
… LV myocardium from patients with sinus rhythm and patients … with impaired Ca 2+ handling,
prolonged action potentials, … human model, we used human iPSC-CM for chronic AF-…
prolonged action potentials, … human model, we used human iPSC-CM for chronic AF-…
Fibrotic remodeling during persistent atrial fibrillation: In silico investigation of the role of calcium for human atrial myofibroblast electrophysiology
… model with Ca 2+ handling to an atrial myocyte affects the action potential under electrical
remodeling due to persistent … a planar wave propagation during sinus rhythm with 10 pulses at …
remodeling due to persistent … a planar wave propagation during sinus rhythm with 10 pulses at …
Enhanced Ca2+-Dependent SK-Channel Gating and Membrane Trafficking in Human Atrial Fibrillation
… and apamin caused larger action potential prolongation in cAF- … improved human atrial
cardiomyocyte computational model … in right atrial (RA)-cardiomyocytes from sinus rhythm control (…
cardiomyocyte computational model … in right atrial (RA)-cardiomyocytes from sinus rhythm control (…
[HTML][HTML] PITX2 upregulation increases the risk of chronic atrial fibrillation in a dose-dependent manner by modulating IKs and ICaL—insights from human atrial …
… Ca 2+ current (I CaL ) reduction observed in isolated right … -Nattel (CRN) model of human
atrial action potentials (APs) was … These cell models for sinus rhythm (SR) and CAF were then …
atrial action potentials (APs) was … These cell models for sinus rhythm (SR) and CAF were then …
… -Conductance Calcium-Activated Potassium Current (IK,Ca) Leads to Differential Atrial Electrophysiological Effects in a Horse Model of Persistent Atrial Fibrillation
… fibrillation (AF) and to maintain sinus rhythm. However, it has been hypothesized that the …
absence of action potential duration (APD) and the aERP prolonging effect of K Ca 2 inhibition. …
absence of action potential duration (APD) and the aERP prolonging effect of K Ca 2 inhibition. …
[HTML][HTML] Altered calcium handling produces reentry-promoting action potential alternans in atrial fibrillation–remodeled hearts
T Liu, F Xiong, XY Qi, J Xiao, L Villeneuve, I Abu-Taha… - JCI insight, 2020 - ncbi.nlm.nih.gov
… Atrial fibrillation (AF) alters atrial cardiomyocyte (ACM) Ca 2+ … remodeling on Ca 2+ -related
action potential dynamics and … human atrial model, they noted a critical role of Ca 2+ -driven …
action potential dynamics and … human atrial model, they noted a critical role of Ca 2+ -driven …
Dual effects of the small-conductance Ca2+-activated K+ current on human atrial electrophysiology and Ca2+-driven arrhythmogenesis: an in silico study
… regulate the dynamics of the cardiac action potential (AP) on a … normal sinus rhythm (nSR)
patient samples. Here, we use … with our 3D model of the human atrial myocyte integrating 143 …
patient samples. Here, we use … with our 3D model of the human atrial myocyte integrating 143 …
Impaired Intracellular Calcium Buffering Contributes to the Arrhythmogenic Substrate in Atrial Myocytes From Patients With Atrial Fibrillation
FE Fakuade, D Hubricht, V Möller, I Sobitov, A Liutkute… - Circulation, 2024 - ahajournals.org
… Ca 2+ release events and developed action potential alternans at … samples of patients in
sinus rhythm (control) and persistent … mouse heart model to directly link reduced cytosolic Ca 2+ …
sinus rhythm (control) and persistent … mouse heart model to directly link reduced cytosolic Ca 2+ …
A detailed mathematical model of the human atrial cardiomyocyte: integration of electrophysiology and cardiomechanics
… The model couples a modified version of the action potential (AP) … human atrial cellular
model with MER integration that is computationally efficient and exhibits a detailed temporal Ca2…
model with MER integration that is computationally efficient and exhibits a detailed temporal Ca2…
Age-dependent effects of chronic atrial fibrillation remodeling in population of human atrial cardiomyocyte models
T Nesterova, D Shmarko, K Ushenin… - AIP Conference …, 2020 - pubs.aip.org
… observed effects of aging on action potential (AP) and … Also, this model describes intracellular
Ca2+ dynamics, … AP recordings in atrial trabeculae from patients with sinus rhythm (SR) …
Ca2+ dynamics, … AP recordings in atrial trabeculae from patients with sinus rhythm (SR) …