[HTML][HTML] Human leukocyte antigen (HLA) and cancer immunotherapy: HLA-dependent and-independent adoptive immunotherapies

C Wang, C Xiong, YC Hsu, X Wang, L Chen - Annals of Blood, 2020 - aob.amegroups.org
… to immune checkpoint inhibitors than patients with low HLA-I … HLAs presents tumor antigens
to T cells to facilitate the … class II molecules expression were induced on certain tumor cells …

The potential of soluble human leukocyte antigen molecules for early cancer detection and therapeutic vaccine design

AL Kessler, MJ Bruno, SI Buschow - Vaccines, 2020 - mdpi.com
… such as immune checkpoint inhibition, therapeutic vaccines, … HLA-I molecules present
peptides derived from … be explained by differential induction of surface and soluble HLA-G, …

Role of human leukocyte antigen system as a predictive biomarker for checkpoint-based immunotherapy in cancer patients

F Sabbatino, L Liguori, G Polcaro, I Salvato… - International journal of …, 2020 - mdpi.com
… by tightly bound peptides derived from proteins degraded … ability of tumor cells to process
and present tumor antigens to … BRAF inhibitor vemurafenib strengthens the induction of HLA

Synthetic tumor-specific antigenic peptides with a strong affinity to HLA-A2 elicit anti-breast cancer immune response through activating CD8+ T cells

W Shi, Q Qiu, Z Tong, W Guo, F Zou, Z Feng… - European journal of …, 2020 - Elsevier
… A1-restricted antigenic peptides, which exhibited prominent inhibitingtumor antigens (a
“non-self” component) into the body, the antitumor effect can be initiated, which is mainly caused

Human leukocyte antigen class I antigen-processing machinery upregulation by anticancer therapies in the era of checkpoint inhibitors: a review

A Sadagopan, T Michelakos, G Boyiadzis… - JAMA …, 2022 - jamanetwork.com
… Defects in human leukocyte antigen (HLA) class I antigen-… of HLA class I antigen/tumor
antigenderived peptide … protein (MAVS) by inducing transcription and cytoplasmic translocation …

Human leukocyte antigen and tumor immunotherapy

DH Liu, FF Mou, M An, P Xia - … Journal of Oncology, 2023 - spandidos-publications.com
… and other types of tumor antigens has mainly focused on MHC class I molecule-restricted
antigens (106). However, … In addition, HLA-G can also inhibit the secretion of cytokines, induce

Novel HLA-A2 restricted antigenic peptide derivatives with high affinity for the treatment of breast cancer expressing NY-ESO-1

W Shi, Z Tong, Q Qiu, N Yue, W Guo, F Zou, D Zhou… - Bioorganic …, 2020 - Elsevier
… , affinity of the peptides to human leukocyte antigen-A2 (HLA-A2) … that increased expression
of tumor antigens would improve the … Importantly, an obvious inhibition in tumor growth was …

HLA-A2.1-restricted ECM1-derived epitope LA through DC cross-activation priming CD8+ T and NK cells: a novel therapeutic tumour vaccine

Z Yu, W Liu, Y He, M Sun, J Yu, X Jiao, Q Han… - Journal of hematology & …, 2021 - Springer
… Cytotoxic T lymphocyte (CTL) epitopes derived from tumour antigens … -induced upregulation
of p38 phosphorylation level, we found that in DCs treated with TAK242 (a specific inhibitor

The human leukocyte antigen G as an immune escape mechanism and novel therapeutic target in urological tumors

S Jasinski-Bergner, M Eckstein, H Taubert… - Frontiers in …, 2022 - frontiersin.org
… -G) is a potent regulatory protein involved in the induction of … also within the tumor, such as
eg the loss of tumor antigens, … by therapeutic HLA-G inhibition in HLA-G expressing tumors (…

Two unique HLA-A* 0201 restricted peptides derived from cyclin E as immunotherapeutic targets in leukemia

H He, Y Kondo, K Ishiyama, G Alatrash, S Lu, K Cox… - Leukemia, 2020 - nature.com
induction of G1 cell cycle arrest [34]. In CML, targeting the peroxisome proliferator-activated
receptor alpha and gamma led to growth inhibition … used for MHC-I antigen presentation [36, …