Human mesenchymal stromal cells small extracellular vesicles attenuate sepsis-induced acute lung injury in a mouse model: the role of oxidative stress and the …

J Chen, C Li, Z Liang, C Li, Y Li, Z Zhao, T Qiu, H Hao… - Cytotherapy, 2021 - Elsevier
mesenchymal stem cells (MSCs) might reduce lung inflammation and ameliorate lung injury
… The severity of lung injury was blindly scored by two experienced investigators. Compared …

Hypothesis for the management and treatment of the COVID-19-induced acute respiratory distress syndrome and lung injury using mesenchymal stem cell-derived …

M Taghavi-Farahabadi, M Mahmoudi, S Soudi… - Medical hypotheses, 2020 - Elsevier
… is a mesenchymal stem cell (MSC). MSCs suppress inflammation and reduce lung injury
of the family, severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East …

… Capacity of Exosomes Derived from Human Adipose Tissue, Bone Marrow, and Umbilical Cord Mesenchymal Stem Cells in Sepsis‐Induced Acute Lung Injury

H Deng, L Zhu, Y Zhang, L Zheng, S Hu… - … and cellular …, 2022 - Wiley Online Library
… levels in the lung tissues and decreasing the total protein … mild to severe, with higher scores
indicating more severe injury. … marker CD45 (Figure 1(e)). These observations confirmed that …

[HTML][HTML] Mesenchymal stromal cells reduce evidence of lung injury in patients with ARDS

KD Wick, A Leligdowicz, H Zhuo, LB Ware… - JCI insight, 2021 - ncbi.nlm.nih.gov
… First, airspace biomarkers in patients in the START trial provide evidence of the biologic
benefit of MSCs for reducing the severity of acute lung injury in patients with ARDS and bolster …

Therapeutic potential of mesenchymal stem/stromal cell-derived secretome and vesicles for lung injury and disease

A Liu, X Zhang, H He, L Zhou, Y Naito… - Expert opinion on …, 2020 - Taylor & Francis
… (MSC), as a therapeutic for acute lung injury (ALI) holds … injury decreased the alveolar influx
of inflammatory cells and … primed human umbilical cord MSC more effectively attenuated E

A randomized trial of mesenchymal stromal cells for moderate to severe acute respiratory distress syndrome from COVID-19

…, A Duggal, ME Marks, J Hupf, E Fernandes… - … journal of respiratory …, 2023 - atsjournals.org
… Coronavirus disease (COVID-19)-induced acute respiratorymesenchymal stromal cells
(MSCs) may improve lung injury … as being alive with a decrease in ARDS scale severity. Clinical …

[HTML][HTML] Heat shock preconditioning mesenchymal stem cells attenuate acute lung injury via reducing NLRP3 inflammasome activation in macrophages

H Lv, X Yuan, J Zhang, T Lu, J Yao, J Zheng… - Stem cell research & …, 2021 - Springer
… pathological changes and lung damage-related indexes, reduced the … We assessed the
severity of lung injury in each group to … 2e, the apoptotic index of the lung endothelium obviously …

[HTML][HTML] Microvesicles derived from human Wharton's jelly mesenchymal stem cells enhance autophagy and ameliorate acute lung injury via delivery of miR-100

W Chen, J Zhou, S Zhou, Y Zhang, T Ji, X Zhang… - Stem cell research & …, 2020 - Springer
… characterized by a severe inflammatory response of lung injuries and damage to the …
restored lung protein permeability and reduced inflammation in ALI mice induced by E. coli …

[HTML][HTML] Mesenchymal stem cell-based therapy as an alternative to the treatment of acute respiratory distress syndrome: current evidence and future perspectives

S Fernández-Francos, N Eiro… - International journal of …, 2021 - mdpi.com
… of mesenchymal stem cells (MSCs) in acute lung injury (ALI) … pandemic by severe acute
respiratory syndrome coronavirus 2 (… decrease in pro-inflammatory cytokines at the lung injury

Mesenchymal stromal cell extracellular vesicles rescue mitochondrial dysfunction and improve barrier integrity in clinically relevant models of ARDS

JD Silva, Y Su, CS Calfee, KL Delucchi… - … Respiratory Journal, 2021 - Eur Respiratory Soc
… associated with decreased inflammation and injury in the in vivo models of acute lung injury
[… MSC-EVs by pulmonary cells was visualised by Nikon Eclipse Ti-E microscopy. EVs were …