… Neural tube defects arise early in human embryogenesis when the neural tube, the precursor
to the brain and spinal cord, fails to properly close during neurulation. Failure to complete …

… MJ (2012) A consideration of the evidence that genetic defects in planar cell polarity contribute
to the etiology of human neural tube defects. Birth Defects Res A Clin Mol Teratol 94:824–…

… Thus, the complex nature of gene-environment interactions requires the development of
more sophisticated approaches utilizing the tools of contemporary molecular biology to dissect …

… Neural tube defects (NTDs) consist of severe structural malformations of the brain and
spinal cord and are the second most common structural birth defect in humans, accounting for …

… for study in the human NTDs etiology [19]. There are 240 mouse mutants and strains with
neural tube defects which identify the genes needed for embryonic neural tube closure (NTC) […

… of genes, which presents many points of failure leading to NTDs. When attempting to
understand the causes of neural tube defects, one can start by surveying the known genetic …

… neural tube. NTDs are classified based on the extent and position of the opening of the
neural tube, … The causes of NTDs are genetic, involving hundreds of genes, that intersect with …

… Although the incidence of spina bifida is thought to be multifactorial, advances in genetic
and molecular biology studies have pointed to polymorphisms in C677T of the MTHFR gene …

… on the genetic background of … genetic, molecular, and cellular basis of neural tube closure,
as well as to our understanding of the causes and prevention of this devastating birth defect…

… However, the mechanisms of DNA methylation at cellular, molecular, or genetic levels
during neural tube development remain unclear. Large-scale high-throughput techniques and …